Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress
| Autor: | Andrea Granados-Juárez, Nelly Maritza Vega-Rivera, Erika Monserrat Estrada-Camarena, Leonardo Ortiz-López, Gerardo Ramírez-Rodríguez |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neurogenesis Hippocampus Citalopram Hippocampal formation Melatonin 03 medical and health sciences Mice 0302 clinical medicine Internal medicine medicine Animals Chronic stress Mice Inbred BALB C business.industry Chemokine CX3CL1 Depression General Neuroscience Dentate gyrus 030104 developmental biology Endocrinology Antidepressant Microglia business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroscience. 440 |
| ISSN: | 1873-7544 |
| Popis: | Depression may be precipitated by the negative impact of chronic stress, which is considered to play a key role in this neuropsychiatric disorder. Interestingly, depressed patients show decreased levels of melatonin. This hormone acts pro-neurogenic and exhibits anti-depressant effects in rodent models of predictive antidepressant-like effects. However, the benefits of melatonin in reversing the deleterious effects of chronic mild stress on the alterations in behaviour and in the neurogenic niche of the hippocampus in male BALB/c mice are unknown. In this study, we compared the effects of melatonin (2.5 mg/kg) and citalopram (5 mg/kg), an antidepressant drug belonging to the selective serotonin reuptake inhibitors, in male BALB/c mice exposed to chronic mild stress (CMS). We also investigated the potential effects of melatonin and citalopram on microglial cells, hippocampal neurogenesis and peripheral cytokine profiles. Melatonin and citalopram induced similar antidepressant-like activities that occurred with some of the the following findings: (1) reversal of the morphological alterations in microglia; (2) reversal of the decreased immunoreactivity to CX3CL1 and CX3CR1 in the dentate gyrus; (3) positive regulation of cell proliferation, survival and complexity of the dendritic trees of doublecortin-cells; and (4) modifications of peripheral CX3CL1 expression. This outcome is consistent with the hypothesis about the antidepressant-like effect of melatonin and supports its relevance as a modulator of the niche in the dentate gyrus. |
| Databáze: | OpenAIRE |
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