Sinonasal disorders in hematopoietic stem cell transplantation
| Autor: | Eulalia Sakano, Afonso Celso Vigorito, Ester Maria Danieli Nicola, Lucas Ricci Bento, Erica Ortiz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation chemical and pharmacologic phenomena Disease Gastroenterology immune system diseases Internal medicine Doença enxerto-hospedeiro medicine Humans Sinusitis Clinical treatment Retrospective Studies Rhinitis business.industry Hematopoietic Stem Cell Transplantation Myeloid leukemia Immunosuppression Retrospective cohort study Transplante de células-tronco hematopoéticas lcsh:Otorhinolaryngology Hematologic Diseases lcsh:RF1-547 Graft vs. host disease Transplantation Condutas terapêuticas Sinusite surgical procedures operative Otorhinolaryngology Immunology Chronic Disease Therapeutic conducts Chronic gvhd business |
| Zdroj: | Brazilian Journal of Otorhinolaryngology, Vol 80, Iss 4, Pp 285-289 (2014) Brazilian Journal of Otorhinolaryngology v.80 n.4 2014 Brazilian Journal of Otorhinolaryngology Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) instacron:ABORL-CCF |
| ISSN: | 1808-8686 |
| Popis: | INTRODUCTION: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression. OBJECTIVE: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between rhinosinusitis and chronic graft vs. host disease (GVHD) and type of transplantation, clinical treatment, surgical treatment, and survival. METHODS: this was a retrospective study in a tertiary university hospital. A total of 95 patients with hematological diseases undergoing HSCT between 1996 and 2011 were selected. RESULTS: chronic myeloid leukemia was the most prevalent disease. The type of transplant most often performed was the allogenic type (85.26%). The frequency of rhinosinusitis was 36%, with no difference between the autologous and the allogenic types. Chronic GVHD occurred in 30% of patients. Patients with GVHD had a higher frequency and recurrence of rhinosinusitis, in addition to more frequent need for endoscopic sinusectomy and decreased overall survival. CONCLUSION: there was a higher frequency of rhinosinusitis in HSCT and GVHD. The type of transplant does not appear to predispose to the occurrence of rhinosinusitis. GVHD seems to be an aggravating factor and requires a more stringent treatment. |
| Databáze: | OpenAIRE |
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