Crystal Structure of Murine Tcl1 Oncoprotein and Conserved Surface Features of the Molecules of the Tcl1 Family
| Autor: | Carlo M. Croce, Robert W. Harrison, John M. Petock, Yuan-Fang Wang, Garrett C. Du Bois, Ivan Y. Torshin, Robert T. Weber |
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| Rok vydání: | 2018 |
| Předmět: |
Genetics
lcsh:T Stereochemistry Chemistry lcsh:R Short Report lcsh:Medicine General Medicine Crystal structure lcsh:Technology General Biochemistry Genetics and Molecular Biology Protein tertiary structure Sequence identity Beta barrel Molecule lcsh:Q Human genome Binding site lcsh:Science General Environmental Science Sequence (medicine) |
| Zdroj: | The Scientific World Journal The Scientific World Journal, Vol 2, Pp 119-120 (2002) |
| ISSN: | 1537-744X |
| Popis: | INTRODUCTION. The structures of members of the Tcl1 oncoprotein family are being studied in order to understand their roles in lymphocyte biology and their development of lymphocytic diseases[1-3]. These ~15 kD proteins share 25–80% sequence identity between the members of the family. No sequence similarity was found with other human genes suggesting a unique cellular role(s). Family members share an uncommon tertiary structure of an eight-stranded beta barrel. Recently, the crystal structure of murine Tcl1 was determined[3]. The three structures were analyzed to reveal conserved features indicative of a potential binding site for an interacting protein. |
| Databáze: | OpenAIRE |
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