Antagonism of scopolamine-induced memory impairments in rats by the muscarinic agonist RU 35 926 (CI-979)
| Autor: | A.-M Palou, F. Barzaghi, C Oberlander, M M'Harzi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Agonist Dihydropyridines medicine.medical_specialty medicine.drug_class Scopolamine Clinical Biochemistry Muscarinic Agonists Toxicology Synaptic Transmission Biochemistry Muscarinic agonist Behavioral Neuroscience Memory Oral administration Internal medicine Oximes Muscarinic acetylcholine receptor medicine Animals Rats Wistar Maze Learning Biological Psychiatry Cholinesterase Pharmacology Psychotropic Drugs Radial arm maze biology business.industry Muscarinic antagonist Rats Memory Short-Term Endocrinology Anesthesia Tacrine biology.protein Cholinergic business medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 51:119-124 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(94)00369-t |
| Popis: | The promnesic effects of RU 35 926 (CI-979), a muscarinic receptor agonist, were evaluated on memory impairments induced by the muscarinic antagonist scopolamine, using a radial arm maze task, in comparison with tetrahydroaminoacridine (THA), a cholinesterase inhibitor. Groups of rats were trained in a standard version of the radial maze until they had attained an asymptotic level of performance. The animals were then retested with one trial a day. Twenty minutes before each retest, the rats were given subcutaneous administration of 0.1 mg/kg scopolamine. Oral administration of RU 35 926 (0.02, 0.05, 0.1, 0.2, and 0.5 mg/kg) 30 min before memory retest markedly reduced or suppressed the scopolamine-induced deficit. This reduction was evidenced by a significant decrease in the different types of errors and an increase in the number of correct responses. THA (3 mg/kg, intraperitoneally or orally) given 20 min to testing also significantly reduced or suppressed the scopolamine-induced deficits. These results show that RU 35 926 possesses the capacity to reduce memory impairments induced by a deficit of cholinergic transmission in the rat. |
| Databáze: | OpenAIRE |
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