Influence of Sibutramine on Energy Expenditure in African American Women
| Autor: | Dennis H. Sullivan, Xiaolan Liu, Raymond D. Starling |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Black People Medicine (miscellaneous) Overweight Placebo Oxygen Consumption Endocrinology Double-Blind Method Heart Rate Weight loss Internal medicine Appetite Depressants Heart rate Humans Medicine Resting energy expenditure Obesity Exercise Cross-Over Studies business.industry Public Health Environmental and Occupational Health Liter medicine.disease Premenopause Female Basal Metabolism medicine.symptom Energy Metabolism business Cyclobutanes Food Science Sibutramine medicine.drug |
| Zdroj: | Obesity Research. 9:251-256 |
| ISSN: | 1071-7323 |
| DOI: | 10.1038/oby.2001.29 |
| Popis: | OBJECTIVE African American women have a high prevalence of obesity, which partially may be explained by their lower rates of resting energy expenditure (REE). The aim of this study was to examine the influence of acute sibutramine administration on REE and post-exercise energy expenditure in African American women. RESEARCH METHODS AND PROCEDURES A total of 15 premenopausal, African American women (age, 29 +/- 5 years; body fat, 38 +/- 7%) completed a randomized, double-blind cross-over design with a 30-mg ingestion of sibutramine or a placebo. Each trial was completed a month apart in the follicular phase and included a 30-minute measurement of REE 2.5 hours after sibutramine or placebo administration. This was followed by 40 minutes of cycling at approximately 70% of peak aerobic capacity and a subsequent 2-hour measurement of post-cycling energy expenditure. RESULTS There was no difference (p > 0.05) in REE (23.70 +/- 2.81 vs. 23.69 +/- 2.95 kcal/30 min), exercise oxygen consumption (1.22 +/- 0.15 vs. 1.25 +/- 0.15 liter/min), and post-cycling energy expenditure (104.2 +/- 12.7 vs. 104.9 +/- 11.4 kcal/120 min) between the sibutramine and placebo trials, respectively. Cycling heart rate was significantly higher (p = 0.01) during the sibutramine (158 +/- 14 beats/min) vs. placebo (150 +/- 12 beats/min) trials. DISCUSSION These data demonstrate that acute sibutramine ingestion does not increase REE or post-exercise energy expenditures but does increase exercising heart rate in overweight African American women. Sibutramine may, therefore, impact weight loss through energy intake and not energy expenditure mechanisms. |
| Databáze: | OpenAIRE |
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