Sphingofungins A,B,C, and d; a new family of antifungal agents. I. Fermentation, isolation, and biological activity
| Autor: | Vanmiddlesworth Frank L, Robert A. Giacobbe, Kenneth E. Wilson, Ann M. Edison, George M. Garrity, Jon D. Polishook, Ken Bartizal, Richard L. Monaghan, Robert A. Fromtling, Marcia Zweerink, Lopez Maria B, Walter Rozdilsky, Judith A. Bland |
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| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Cryptococcus neoformans Antifungal Agents biology medicine.drug_class Aspergillus fumigatus Microorganism Antibiotics Biological activity Fungi imperfecti biology.organism_classification Microbiology chemistry.chemical_compound chemistry Fermentation Drug Discovery Fatty Acids Unsaturated medicine Glycerol Amino Acids |
| Zdroj: | The Journal of Antibiotics. 45:861-867 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.45.861 |
| Popis: | In screening for antifungal inhibitors from fungi, four related antifungal agents have been isolated from the cultivation of Aspergillus fumigatus ATCC 20857. These agents were initially produced by the microorganism growing on a solid millet-based medium. A liquid medium containing both glucose and glycerol has also been developed in which these antibiotics are produced in two phases. These novel compounds, sphingofungins A, B, C, and D, show a limited spectrum of antifungal activity but were especially effective against Cryptococcus species. |
| Databáze: | OpenAIRE |
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