Topical heat shock protein 70 prevents imiquimod-induced psoriasis-like inflammation in mice
| Autor: | Julia Lax, Jennifer Harvey, M. Elaine Husni, Michael Tytell, Paul E. DiCorleto, Unnikrishnan M. Chandrasekharan, Federico G. Seifarth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.drug_class Short Communication Skin Cream Inflammation Imiquimod Disease Administration Cutaneous Biochemistry Anti-inflammatory 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system Psoriasis medicine Animals HSP70 Heat-Shock Proteins Mice Inbred BALB C biology business.industry Cell Biology medicine.disease 030104 developmental biology Immunology biology.protein Cytokines medicine.symptom Antibody business medicine.drug |
| Popis: | Psoriasis is a chronic inflammatory skin disease with systemic manifestations and potential genetic etiology. The newest treatments utilize antibodies against one of several cytokines known to underlie the inflammatory signaling molecules that produce the skin and systemic symptoms. However, these agents must be regularly injected, and they may compromise the normal responses of the immune system. Furthermore, they do not address the causes of the abnormal immunoregulatory responses of the disease because the etiology is not yet completely understood. In this short-term treatment study, the potential anti-inflammatory activity of an alfalfa-derived Hsp70-containing skin cream (aHsp70) was tested on imiquimod (IMQ)-induced psoriasis-like lesions in wild-type mice. Treatment of the mice with the aHsp70 skin cream simultaneously with the imiquimod application mitigated the induction of psoriatic-like lesions and correlated with altered expression of various skin cytokines. |
| Databáze: | OpenAIRE |
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