Sumatriptan Succinate Transdermal Delivery Systems for The Treatment of Migraine
| Autor: | S. del Rio-Sancho, C. Balaguer-Fernández, A. Femenía-Font, Alicia López-Castellano, Virginia Merino |
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| Rok vydání: | 2008 |
| Předmět: |
Polymers
Swine Chemistry Pharmaceutical Drug Compounding Migraine Disorders Skin Absorption Pharmaceutical Science macromolecular substances Absorption (skin) Methylcellulose Pharmacology Administration Cutaneous Permeability Dosage form chemistry.chemical_compound Polymethacrylic Acids Plasticizers Sumatriptan Succinate medicine Animals Sorbitol Technology Pharmaceutical Vasoconstrictor Agents Skin Transdermal Drug Carriers integumentary system Sumatriptan Chemistry technology industry and agriculture Plasticizer Povidone Azepines Iontophoresis Permeation Propylene Glycol Serotonin Receptor Agonists Kinetics Polyvinyl Alcohol Methyl cellulose Diffusion Chambers Culture Tissue Adhesives Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 97:2102-2109 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.21129 |
| Popis: | We have successfully obtained sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propylenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of sumatriptan succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically significant increment with respect to the PVP and PVP-PVA formulations (p0.05). Azone incorporation into the systems produced an increment in the sumatriptan flux values of all three transdermal systems with respect to those of the controls (p0.05). In addition, the application of iontophoresis to the wet methyl cellulose-Azone formulation produced a much higher increase of sumatriptan transdermal flux. |
| Databáze: | OpenAIRE |
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