Pituitary-testicular function in patients with alcoholic cirrhosis of the liver
| Autor: | S G Johnsen, Lars Bo Svendsen, O. Dietrichson, U. A. Brodthagen, S. Micic, C. Gluud, M. Bahnsen, P. Bennett, S. Svenstrup |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcoholic liver disease Cirrhosis Estrone Clinical Biochemistry Biochemistry Sex hormone-binding globulin Liver Cirrhosis Alcoholic Internal medicine Sex Hormone-Binding Globulin Testis medicine Humans Testosterone Aged Testicular atrophy biology Estradiol Liver cell Hypogonadism General Medicine Dehydroepiandrosterone Middle Aged medicine.disease Prolactin Endocrinology Pituitary Gland biology.protein Gynecomastia Liver function Luteinizing hormone Gonadotropins |
| Zdroj: | European journal of clinical investigation. 11(6) |
| ISSN: | 0014-2972 |
| Popis: | In forty-two patients with alcoholic liver cirrhosis and without recent alcohol ingestion the pituitary-testicular function was studied in an effort to relate the endocrine abnormalities with the degree of liver cell dysfunction, evaluated on a quantitative basis. Compared with values in twenty-one healthy controls, we found significantly elevated serum oestrone, oestradiol, follicle-stimulating hormone, luteinizing hormone and prolactin (P less than 0.01). Serum dehydro-epiandrosterone and dehydroepiandrosterone sulphate were significantly reduced in the cirrhotics (P less than 0.01), whereas serum testosterone was not significantly different from that in the controls. Raised levels of sex-hormone binding globulin were found in 71% (22/31) of the patients (median 8 x 10(-18) mol/l, range 3-17 x 10(-8) mol/l). The incidence of gynaecomastia (38%), cutaneous spiders (67%), testicular atrophy (24%) and reduced axillary hair (71%) was without significant relation to raised levels of sex-hormone binding globulin or progressively reduced liver function. In the presence of clinical or hormonal hypo-gonadism we found evidence of a state of primary hypogonadism together with an inadequate secretion of gonadotropins. The state of hyperoestrogenaemia and the concentration of gonadotropins were significantly correlated to the hepatic synthesis of coagulation factors. |
| Databáze: | OpenAIRE |
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