The Role of Glucocorticoids in Inflammatory Diseases
| Autor: | Reichardt, Sybille D., Amouret, Agathe, Muzzi, Chiara, Vettorazzi, Sabine, Tuckermann, Jan P., Lühder, Fred, Reichardt, Holger M., Harris, James |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Multiple Sklerose
rheumatoid arthritis QH301-705.5 Review Inflammatory bowel diseases Graft versus host disease multiple sclerosis Models Biological Lungenkrankheit Multiple sclerosis graft-versus-host-disease DDC 570 / Life sciences inflammatory bowel disease ddc:570 glucocorticoid receptor Animals Humans Transplantat-Wirt-Reaktion Rheumatoid arthritis Biology (General) Glucocorticoids Inflammation Chronische Darmentzündung Rheumatoide Arthritis Nanopartikel asthma Glucocorticoids Receptors Disease Models Animal Phenotype acute lung injury Bronchialasthma Nanoparticles |
| Zdroj: | Cells, Vol 10, Iss 2921, p 2921 (2021) Cells |
| ISSN: | 2073-4409 |
| Popis: | For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being made to improve their therapeutic index. In this review, we illustrate the mechanisms and target cells of GCs in the pathogenesis and treatment of some of the most frequent inflammatory disorders affecting the central nervous system, the gastrointestinal tract, the lung, and the joints, as well as graft-versus-host disease, which often develops after hematopoietic stem cell transplantation. In addition, an overview is provided of novel approaches aimed at improving GC therapy based on chemical modifications or GC delivery using nanoformulations. GCs remain a topic of highly active scientific research despite being one of the oldest class of drugs in medical use. publishedVersion |
| Databáze: | OpenAIRE |
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