Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time

Autor: Makoto Kobayashi, Yuji Fuse
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Keap1
NF-E2-Related Factor 2
Hydra Nrf
Pharmaceutical Science
Review
Nrf2
Analytical Chemistry
Fight-or-flight response
lcsh:QD241-441
03 medical and health sciences
Structure-Activity Relationship
0302 clinical medicine
Species Specificity
yeast Yap1
lcsh:Organic chemistry
Stress
Physiological
Drug Discovery
Animals
Physical and Theoretical Chemistry
Gene
Zebrafish
Caenorhabditis elegans
mouse
Genetics
Kelch-Like ECH-Associated Protein 1
biology
Mechanism (biology)
C. elegans Skn-1
Organic Chemistry
Genetic data
Genome project
biology.organism_classification
zebrafish
Biological Evolution
Keap1 nrf2
Drosophila Cnc
030104 developmental biology
Gene Expression Regulation
Chemistry (miscellaneous)
Evolutionary biology
030220 oncology & carcinogenesis
Molecular Medicine
evolutionary history
anti-stress system
Protein Binding
Signal Transduction
Zdroj: Molecules, Vol 22, Iss 3, p 436 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
ISSN: 1420-3049
Popis: The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against oxidative and xenobiotic stress. Its regulatory mechanisms, e.g., stress-sensing mechanism, proteasome-based regulation of Nrf2 activity and selection of target genes, have been elucidated mainly in mammals. In addition, emerging model animals, such as zebrafish, fruit fly and Caenorhabditis elegans, have been shown to have similar anti-stress systems to mammals, suggesting that analogous defense systems are widely conserved throughout the animal kingdom. Experimental evidence in lower animals provides important information beyond mere laboratory-confined utility, such as regarding how these systems transformed during evolution, which may help characterize the mammalian system in greater detail. Recent advances in genome projects of both model and non-model animals have provided a great deal of useful information toward this end. We herein review the research on Keap1-Nrf2 and its analogous systems in both mammals and lower model animals. In addition, by comparing the amino acid sequences of Nrf2 and Keap1 proteins from various species, we can deduce the evolutionary history of the anti-stress system. This combinatorial approach using both experimental and genetic data will suggest perspectives of approach for researchers studying the stress response.
Databáze: OpenAIRE
Externí odkaz: