Integrated view of Vibrio cholerae in the Americas

Autor: Marcial Leonardo Lizárraga-Partida, Alejandro Cravioto, Alison E. Mather, Daryl Domman, David M. Aanensen, Elisabeth Njamkepo, Gabriella Delgado, Rosario Morales-Espinosa, Pablo Kuri-Morales, Marie-Laure Quilici, Julian Parkhill, Josefina Campos, Gordon Dougan, François-Xavier Weill, Cheryl L. Tarr, Patrick A. D. Grimont, Matthew J. Dorman, Christiane Bouchier, Ankur Mutreja, Nicholas R. Thomson
Přispěvatelé: The Wellcome Trust Sanger Institute [Cambridge], Bactéries pathogènes entériques (BPE), Institut Pasteur [Paris], University of Cambridge [UK] (CAM), Universidad Nacional Autónoma de México (UNAM), Biodiversité des Bactéries Pathogènes Émergentes, Centro de Investigacion Cientifica y de Education Superior de Ensenada [Mexico] (CICESE), Génomique (Plate-Forme) - Genomics Platform, Secretaría de Salud, Mexico city, Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Administración Nacional de Laboratorios e Institutos de Salud ‘Carlos Malbran' (ANLIS), London School of Hygiene and Tropical Medicine (LSHTM), This study was supported by the Wellcome Trust (grant 098051), the Institut Pasteur, Santé Publique France, and the French government’s Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant no. ANR-10-LABX-62-IBEID). We thank J. Rauzier for technical assistance, A. J. Page, J. Keane, and the sequencing teams at the Wellcome Trust Sanger Institute and the Institut Pasteur, and M. Beale for helpful comments. M.J.D. is supported by a Wellcome Trust Sanger Institute Ph.D. Studentship. A.E.M. is supported by Biotechnology and Biological Sciences Research Council fellowship BB/M014088/1. D.M.A. is supported by the Centre for Genomic Pathogen Surveillance., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris] (IP), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Domman, Daryl [0000-0001-5389-9185], Dorman, Matthew J [0000-0001-7064-6163], Njamkepo, Elisabeth [0000-0001-6791-6003], Delgado, Gabriella [0000-0003-4577-4440], Morales-Espinosa, Rosario [0000-0003-2110-4397], Grimont, Patrick AD [0000-0002-6264-136X], Lizárraga-Partida, Marcial Leonardo [0000-0001-9675-3813], Bouchier, Christiane [0000-0003-3549-1543], Kuri-Morales, Pablo [0000-0002-0704-9507], Tarr, Cheryl L [0000-0001-6290-365X], Dougan, Gordon [0000-0003-0022-965X], Parkhill, Julian [0000-0002-7069-5958], Campos, Josefina [0000-0003-1409-0441], Cravioto, Alejandro [0000-0001-7357-0010], Weill, François-Xavier [0000-0001-9941-5799], Thomson, Nicholas R [0000-0002-4432-8505], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Science
Science, American Association for the Advancement of Science, 2017, 358 (6364), pp.789-793. ⟨10.1126/science.aao2136⟩
Science, 2017, 358 (6364), pp.789-793. ⟨10.1126/science.aao2136⟩
ISSN: 0036-8075
1095-9203
DOI: 10.1126/science.aao2136⟩
Popis: Wave upon wave of disease The cholera pathogen, Vibrio cholerae , is considered to be ubiquitous in water systems, making the design of eradication measures apparently fruitless. Nevertheless, local and global Vibrio populations remain distinct. Now, Weill et al. and Domman et al. show that a surprising diversity between continents has been established. Latin America and Africa bear different variants of cholera toxin with different transmission dynamics and ecological niches. The data are not consistent with the establishment of long-term reservoirs of pandemic cholera or with a relationship to climate events. Science , this issue p. 785 , p. 789
Databáze: OpenAIRE
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