Dietary polyphenols enhance optogenetic recall of fear memory in hippocampal dentate gyrus granule neuron subpopulations
| Autor: | Tal Frolinger, Justin Brathwaite, Chad C. Smith, Steven Sims, Giulio Maria Pasinetti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Fear memory Recall QH301-705.5 Dentate gyrus fungi Medicine (miscellaneous) food and beverages Engram Hippocampal formation Biology Optogenetics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Granular cell nervous system Polyphenol Biology (General) General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Communications Biology, Vol 1, Iss 1, Pp 1-8 (2018) |
| ISSN: | 2399-3642 |
| Popis: | Grape-derived polyphenols have been investigated for their role in promoting memory in model systems of stress, but little is known about select subpopulations of neurons that are influenced by polyphenols to improve memory performance. Granule neurons in the hippocampal dentate gyrus are vulnerable to stressors that impair contextual memory function and can be influenced by dietary polyphenols. We utilized a c-fos-tTA/TRE-ChR2 optogenetics model in which neurons activated during fear learning are labeled with ChR2-mCherry and can be optically reactivated in a different context to recapitulate the behavioral output of a related memory. Treatment with dietary polyphenols increased fear memory recall and ChR2-mCherry expression in dentate gyrus neurons, suggesting that dietary polyphenols promote recruitment of neurons to a fear memory engram. We show that dietary polyphenols promote memory function and offer a general method to map cellular subpopulations influenced by dietary polyphenols, in part through the mechanism of c-Fos expression enhancement. Chad Smith et al. show that dietary polyphenols, compounds found in grapes, enable mice to remember fearful events more effectively and map this function to the hippocampal dentate gyrus neurons. This study offers a way to identify the cellular subpopulations regulated by dietary polyphenols. |
| Databáze: | OpenAIRE |
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