Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients

Autor: Jerome R. Lechien, Álvaro Marchan-López, Robson Capasso, Valentin A. Schriever, Byron Maldonado-Alvarado, Ithzel Maria Villarreal, Marta Sanz-Rodriguez, Maria del Mar Martínez Ruiz-Coello, Gabriel Martínez-Capoccioni, Claudio Fragola, Maria Soriano-Reixach, Christian Calvo-Henriquez, Raimundo Andrés Navarro, Elisabeth Ninchritz-Becerra, Franklin Mariño-Sánchez, Alfonso Santamaría-Gadea, Elisabeth Mondragon-Rezola, Petros D. Karkos, Miguel Rodriguez-Iglesias, Miguel Mayo-Yáñez, Irene Rivero-Fernández, Alejandro Rivero-de-Aguilar, Alfredo García-Fernández, Isam Alobid, Carlos Martin-Martin, Carlos M. Chiesa-Estomba, Hugo Pérez-Freixo, Sven Saussez
Přispěvatelé: Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne] (CHUS), Donostia Hospital Universitario San Sebastian, Hospital Universitario 12 de Octubre [Madrid], Hospital Universitario de Fuenlabrada, UNIVERSITE DE SANTIAGO DE COMPOSTELA ESP, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Ramon & Cajal University Hospital, Hospital Universitario Doctor Negrín [Las Palmas de Gran Canaria, Spain], Hôpital Foch [Suresnes], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of Mons [Belgium] (UMONS), University General Hospital of Thessaloniki AHEPA, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Hospital Clinic, IDIBAPS, Universidad de Barcelona, Ciberes, Barcelona, Spain., A Coruña University Hospital [La Corogne, Espagne]
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: European Archives of Oto-Rhino-Laryngology
European Archives of Oto-Rhino-Laryngology, Springer Verlag, 2020, 277 (10), pp.2783-2792. ⟨10.1007/s00405-020-06131-3⟩
ISSN: 0937-4477
1434-4726
DOI: 10.1007/s00405-020-06131-3⟩
Popis: International audience; Objective: COVID-19 patients may present mild symptoms. The identification of paucisymptomatic patients is paramount in order to interrupt the transmission chain of the virus. Olfactory loss could be one of those early symptoms which might help in the diagnosis of COVID-19 patients. In this study, we aim to develop and validate a fast, inexpensive, reliable and easy-to-perform olfactory test for the screening of suspected COVID-19 patients. Study design: Phase I was a case–control study and Phase II a transversal descriptive study. Subjects and methods: Olfaction was assessed with the ethyl alcohol threshold test and symptoms with visual analogue scales. The study was designed in two phases: In Phase I, we compared confirmed COVID-19 patients and healthy controls. In Phase II, patients with suspected COVID-19 infection referred for testing were studied. Results: 275 participants were included in Phase I, 135 in Phase II. The ROC curve showed an AUC of 0.749 in Phase I, 0.737 in Phase II. The cutoff value which offered the highest amount of correctly classified patients was ≥ 2 (10% alcohol) for all age intervals. The odds ratio was 8.19 in Phase I, 6.56 in Phase II with a 75% sensitivity. When cases report normal sense of smell (VAS < 4), it misdiagnoses 57.89% of patients detected by the alcohol threshold test. Conclusion: The olfactory loss assessed with the alcohol threshold test has shown high sensitivity and odds ratio in both patients with confirmed COVID-19 illness and participants with suspected SARS-CoV-2 infection.
Databáze: OpenAIRE
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