DNA damage response and repair data with pharmacological modulators of Tousled
| Autor: | Gulshan Sunavala-Dossabhoy, Prakash Srinivasan Timiri Shanmugam, Gloria Caldito, Arrigo DeBenedetti, Renjith P. Nair, Fleurette Abreo |
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| Rok vydání: | 2016 |
| Předmět: |
Ionizing radiation
0301 basic medicine Gallic acid DNA damage DNA repair Biology lcsh:Computer applications to medicine. Medical informatics Chromatin remodeling 03 medical and health sciences chemistry.chemical_compound lcsh:Science (General) Cytotoxicity Data Article Multidisciplinary Thioridazine Effector Kinase Tousled Molecular biology Small molecule 3. Good health Cell biology 030104 developmental biology chemistry lcsh:R858-859.7 DNA lcsh:Q1-390 |
| Zdroj: | Data in Brief, Vol 7, Iss, Pp 1073-1077 (2016) Data in Brief |
| ISSN: | 2352-3409 |
| DOI: | 10.1016/j.dib.2016.03.075 |
| Popis: | Human Tousled kinase 1 (TLK1) plays an important role in chromatin remodeling, replication, and DNA damage response and repair. TLK1 activity is immediately, but transiently, downregulated after genotoxic insult, and its recovery is important for exit from checkpoint arrest and cell survival after radiation. The data in this article compliments research presented in the paper titled, “Tousled kinase activator, gallic acid, promotes DNA repair and suppresses radiation cytotoxicity in salivary gland cells” [1]. The identification of small molecule activators and inhibitors of TLK1 provided an opportunity to pharmacologically alter the protein׳s activity to elucidate its role in DNA damage response pathways. TLK1 effectors, gallic acid (GA) and thioridazine (THD) activate and inhibit the kinase, respectively, and the data report on the impact of these compounds and the significance of TLK1 to DNA break repair and the survival of human salivary acinar cells. Keywords: Tousled, Ionizing radiation, DNA repair, Gallic acid, Thioridazine |
| Databáze: | OpenAIRE |
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