A Patient with Fulminant Myasthenia Gravis Is Seropositive for Both AChR and LRP4 Antibodies, Complicated by Autoimmune Polyglandular Syndrome Type 3
| Autor: | Noriyuki Matsukawa, Tatsuya Tomonari, Kotaro Mizuno, Keiko Mita, Asami Fujii, Hiroyasu Inoue, Osamu Higuchi, Kentaro Yamada, Masaya Akao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Fulminant 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Ptosis Autoimmune Polyglandular Syndrome Internal medicine Myasthenia Gravis Internal Medicine medicine Humans Receptors Cholinergic Polyendocrinopathies Autoimmune LDL-Receptor Related Proteins Acetylcholine receptor Aged Autoantibodies biology business.industry Thyroidectomy Infant General Medicine medicine.disease Myasthenia gravis Thymectomy biology.protein 030211 gastroenterology & hepatology Female medicine.symptom Antibody business |
| Zdroj: | Internal medicine (Tokyo, Japan). 59(17) |
| ISSN: | 1349-7235 |
| Popis: | This article describes the first reported case of myasthenia gravis (MG) seropositive for both acetylcholine receptor antibody and low-density lipoprotein receptor-related protein 4 antibody, complicated by autoimmune polyglandular syndrome (APS) type 3. The patient exhibited myasthenic weakness restricted to the ocular muscles and ptosis. Severe clinical deterioration ensued with predominant bulbar symptoms. MG rapidly worsened, the patient was intubated, and agranulocytosis due to thiamazole was also present, so it was necessary to perform thyroidectomy with tracheostomy and thymectomy in two phases. Both the double-seropositive MG and the APS were involved in the patient's rapid deterioration. |
| Databáze: | OpenAIRE |
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