Clinical application of protein induced by vitamin K antagonist-II as a biomarker in hepatocellular carcinoma
| Autor: | Cunling Yan, Wenfeng Lu, Nianyue Wang, Zhouchong Wang, Tian Yang, Shu-Yang Dai, Yijie Zheng, Jun Han, Hao Xing, Jianyong Yuan, Liming Cheng |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Population Targeted therapy Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine education neoplasms education.field_of_study business.industry Cancer General Medicine Vitamin K antagonist medicine.disease digestive system diseases Radiation therapy 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Biomarker (medicine) 030211 gastroenterology & hepatology business |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. |
| ISSN: | 1423-0380 |
| Popis: | Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Early diagnosis improves the prognosis. Protein induced by vitamin K antagonist-II (PIVKA-II) is an effective serum biomarker for HCC diagnosis and prognosis. Combined with another serum biomarker α-fetoprotein (AFP), the sensitivity and specificity of HCC diagnosis can be improved to a maximum of 94 and 98.5 %, respectively. PIVKA-II alone or in combination with AFP and/or AFP-L3 was effective in predicting the treatment response and clinical outcome of curative hepatic resection, chemotherapy, targeted therapy, radiotherapy, and liver transplantation. Japanese clinical guidelines recommend the combined use of PIVKA-II and AFP for the diagnosis of HCC, management of high-risk population, and prognosis of anticancer treatment. Further, PIVKA-II as a functional target promoted HCC cell proliferation, invasion, and metastasis by activating c-Met and other signal transduction pathways. Inhibition of PIVKA-II may provide a selective and effective therapy for HCC. |
| Databáze: | OpenAIRE |
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