Risk of dyslipidaemia with antipsychotic drug treatment in Chinese inpatients with mental illness: a hospital-based cohort study
| Autor: | Min Liu, Moning Guo, Qiuyue Ma, Botao Ma, Wenzhan Jing, Juan Li, Jue Liu, Fude Yang, Zhiren Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
China medicine.medical_specialty Multivariate analysis endocrine system diseases Adolescent medicine.medical_treatment lcsh:Medicine Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine lipid disorders Humans Medicine Medical prescription Antipsychotic Dyslipidemias Inpatients business.industry Mental Disorders Medical record Fatty liver lcsh:R nutritional and metabolic diseases General Medicine Mental illness medicine.disease Mental health psychiatry 030227 psychiatry Mental Health business 030217 neurology & neurosurgery Antipsychotic Agents Cohort study |
| Zdroj: | BMJ Open, Vol 11, Iss 1 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesTo determine the association of long-term use of antipsychotics with the risk of dyslipidaemia.DesignA hospital-based cohort study.SettingElectronic health record data of adult mental health inpatients in all 19 specialised psychiatric hospitals in Beijing from 1 January 2005 to 31 December 2018 was obtained.ParticipantsParticipants were inpatients aged 18 years or older with at least two admissions, excluding those with diagnosed dyslipidaemia and fatty liver at the first admission. We included 22 329 adult inpatients with no dyslipidaemia and fatty liver at baseline. The exposure was antipsychotics use, defined as antipsychotics prescription in the treatment procedures of medical record preceding dyslipidaemia diagnosis during the follow-up period. 15 930 (71.34%) had antipsychotics use, and 6399 (28.66%) never had antipsychotics use. We used the length of follow-up as proxy for the duration of antipsychotics exposure.Primary outcome measuresThe primary outcome was newly recorded dyslipidaemia defined by International Classification of Diseases, 10th Revision codes.Results4069 inpatients had newly recorded dyslipidaemia during 73 418.07 person-years, the incidence rate was 5.54 per 100 person-years. The incidence rate was 7.22 per 100 person-years in the exposed group and 3.43 per 100 person-years in the unexposed group. Results of multivariate analysis showed that antipsychotics use was associated with higher risk of dyslipidaemia (adjusted HR, aHR 2.41, 95% CI 2.24 to 2.59, pConclusionsBoth short-term and long-term antipsychotics use was associated with higher risk of dyslipidaemia among Chinese inpatients with mental illness. Dyslipidaemia was especially prominent in young patients and those without hypertension. |
| Databáze: | OpenAIRE |
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