Cell communication: A cyclic-AMP mediated phenomenon
| Autor: | Ger E. P. M. van Venrooij, Joost B. J. Vossenberg, Werner M. A. Hax |
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| Rok vydání: | 1974 |
| Předmět: |
Adenosine monophosphate
medicine.medical_specialty Cell signaling Cell Membrane Permeability Physiology Ecdysterone Biophysics Biology Salivary Glands Membrane Potentials chemistry.chemical_compound Theophylline Internal medicine Cyclic AMP medicine Animals Cyclic adenosine monophosphate Salivary gland Cell Membrane Cell Biology Cell biology Electrophysiology Intercellular Junctions Endocrinology medicine.anatomical_structure Bucladesine chemistry Membrane part Larva Drosophila Intracellular medicine.drug |
| Zdroj: | The Journal of Membrane Biology. 19:253-266 |
| ISSN: | 1432-1424 0022-2631 |
| DOI: | 10.1007/bf01869981 |
| Popis: | Incubation of the salivary glands of the larvae ofDrosophila hydei in a control medium containing 2×10−3 m cyclic adenosine monophosphate (cAMP) induces a considerable increase in passive electrical cel communication. This is caused by a decrease in permeabilty of the nonjunctional membrane part, together with an increase of the permeability of the low-resistance junctions. Similar changes in intercellular communication in the salivary gland ofDrosophila hydei were seen in a majority of experiments in which 10−3 m dibutyryl cycli adenosine monophosphate (dBcAMP), 5×10−3 m theophylline or ecdysterone (100 μg/ml) were added to the control medium. Hyperpolarization of the gland cells can be observed concomitant with the increase in communication. A hypothesis is discussed for a possible molecular regulation of passive electrical cell communication in which the intracellular cAMP level plays a significant part. |
| Databáze: | OpenAIRE |
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