HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia
| Autor: | Sandro Orru, Marcello Trucas, Giovanni Caocci, Giorgio La Nasa, Roberto Cusano, Sara Lai, Carlo Carcassi, Marianna Greco, M Arras, Elisabetta Abruzzese, Bruno Martino, Roberto Littera, Olga Mulas, Sara Galimberti |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research HLA-G clinical 0302 clinical medicine 80 and over Chronic CML Aged 80 and over Leukemia Hematology Chronic myeloid leukemia leukemia polymorphisms alleles outcome myeloid molecules High-Throughput Nucleotide Sequencing Myeloid leukemia Molecular response Adult Aged Antineoplastic Agents Disease-Free Survival Female HLA-G Antigens Humans Leukemia Myelogenous Chronic BCR-ABL Positive Middle Aged Real-Time Polymerase Chain Reaction Treatment Outcome Tumor Escape Oncology Real-time polymerase chain reaction 030220 oncology & carcinogenesis medicine.medical_specialty Human leukocyte antigen Biology 03 medical and health sciences Immune system Internal medicine medicine Allele Immunology BCR-ABL Positive Myelogenous 030215 immunology |
| Zdroj: | Leukemia Research. 61:1-5 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2017.08.005 |
| Popis: | The human leukocyte antigen-G (HLA-G) gene encodes a tolerogenic protein known to promote tumor immune-escape. We investigated HLA-G polymorphisms and soluble molecules (sHLA-G) in 68 chronic myeloid leukemia (CML) patients. Patients with G*01:01:01 or G*01:01:02 allele had higher value of sHLA-G compared to G*01:01:03 (109.2 ± 39.5 vs 39.9 ± 8.8 units/ml; p = 0.03), and showed lower event free survival (EFS) (62.3% vs 90.0%; p = 0.02). The G*01:01:03 allele was associated with higher rates and earlier achievement of deep molecular response (MR)4.5 (100% vs 65%, median of 8 vs 58 months, p = 0.001). HLA-G alleles with higher secretion of sHLA-G seem associated with lower EFS, possibly because of an inhibitory effect on the immune system. Conversely, lower levels of sHLA-G promoted achievement of MR4.5, suggesting increased cooperation with immune system. |
| Databáze: | OpenAIRE |
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