Descriptive epidemiology of parkinsonism in the Canton of Geneva, Switzerland
| Autor: | Pauline Brindel, Pierre R. Burkhard, Nicolas Nicastro, Vanessa Fleury |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Lewy Body Disease
Male medicine.medical_specialty Pediatrics Parkinson's disease Population Context (language use) Progressive supranuclear palsy 03 medical and health sciences 0302 clinical medicine Parkinsonian Disorders Epidemiology Prevalence Medicine Humans 030212 general & internal medicine education Aged Retrospective Studies Aged 80 and over education.field_of_study business.industry Dementia with Lewy bodies Parkinsonism Incidence (epidemiology) Incidence Parkinson Disease Middle Aged Multiple System Atrophy medicine.disease nervous system diseases ddc:616.8 Cross-Sectional Studies Neurology Female Neurology (clinical) Supranuclear Palsy Progressive Geriatrics and Gerontology business 030217 neurology & neurosurgery Switzerland |
| Zdroj: | Parkinsonism & Related Disorders, Vol. 54 (2018) pp. 30-39 |
| ISSN: | 1873-5126 1353-8020 |
| Popis: | Objectives A large descriptive cross-sectional population-based prevalence study as well as a retrospective incidence study were undertaken to ascertain the frequency of Parkinson's Disease (PD) and other types of degenerative and non-degenerative parkinsonism in the Canton of Geneva, Switzerland. Methods An extensive case-finding approach including records from public hospitals, private neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism established between 2003 and 2012 were included. Diagnosis of parkinsonism was ascertained by a movement disorders specialist, based on published and validated consensus diagnostic criteria. Results A total of 1235 living patients with parkinsonism were identified, from which 80% presented with a degenerative form and 20% with a non-degenerative form of parkinsonism. Among the former, PD was the most frequent diagnosis (81%, age-adjusted prevalence: 183/105 inhabitants, age-adjusted average annual incidence: 20/105/year) followed by dementia with Lewy bodies (9%), progressive supranuclear palsy (3.9%), multisystem atrophy (1.9%) and corticobasal syndrome (1.4%). Among non-degenerative parkinsonism, drug-induced parkinsonism was the most frequent diagnosis (43.4%), followed by vascular parkinsonism (37%), normal pressure hydrocephalus (5.1%) and parkinsonism in the context of a psychiatric disorder or functional parkinsonism (3.8%). Crude, age-, sex-specific and age-adjusted prevalence and incidence of all types of parkinsonism are detailed for each diagnosis. Conclusion This is the first Swiss population-based epidemiological study of PD and parkinsonism. It provides an extensive overview of the prevalence and incidence of degenerative and non-degenerative forms of parkinsonism. These data may assist clinicians with their clinical workup. |
| Databáze: | OpenAIRE |
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