Autor: |
C, Bergqvist, L, Fertitta, K, Ezzedine, A, Jannic, O, Zehou, S, Ferkal, P, Combemale, S, Barbarot, J, Mazereeuw-Hautier, E, Sbidian, P, Wolkenstein, Jacques, Zeller |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Journal of the European Academy of Dermatology and Venereology : JEADVReferences. 36(5) |
ISSN: |
1468-3083 |
Popis: |
Neurofibromatosis 1 (NF1) is one of the most common inherited disorders characterized by mutations in the tumour suppressor gene NF1. Its clinical manifestations are highly variable and unpredictable. A specific NF1 mutation does not predict the severity or complications of the disease.The objective of this study was to build an empirical classification scheme without any a priori hypotheses to identify the underlying NF1 subtypes that best explain the observed heterogeneity.We performed latent class analysis (LCA) of 1351 consecutive NF1 patients aged17 years seen between 2002 and 2014. Data and phenotypic features were collected prospectively on a standardized form.The median age was 36.8 (17-81) years. A three-class model showed the best fit: 706 (52%) belonged to the LC1 'Cutaneous neurofibromas' class having preferentially cutaneous neurofibromas (99%), plexiform neurofibromas (63%) and blue-red macules (29%); 593 (44%) belonged to the LC2 'Subcutaneous neurofibromas' class characterized by the presence of at least 10 subcutaneous neurofibromas (21%) and a familial form (77%) and 52 (4%) belonged to the LC3 'Dysmorphic phenotype' class characterized by dysmorphic features (78%) and learning difficulties (87%). Patients in LC1 had a higher likelihood of developing scoliosis (RR = 1.7, 95% confidence interval (CI) [1.2-2.4]). Patients in LC2 were more likely to be men (RR = 1.4, 95% CI [1.1-1.7]). Patients in LC3 were at higher risk of having an optic pathway glioma (RR = 4.8, 95% CI [1.9-11.8]) and epilepsy (RR = 4.5, 95% CI [1.8-11.6]).Our findings invite the performance of a larger cohort study to test whether the various latent classes reflect different underlying genetic modifiers of these phenotypic traits. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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