Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis
| Autor: | J. Michelle Kahlenberg, Robert L. Modlin, K R van Straalen, Olesya Plazyo, Richard E. Burney, Emanual Michael Maverakis, Allison C. Billi, Jill R. Cherry-Bukowiec, Errol P. Prens, John J. Voorhees, Xianying Xing, Jeffrey H. Kozlow, Paul W. Harms, Lam C. Tsoi, Kelly C. Cushing, Christine M. Yee, Allard R. J. V. Vossen, Amanda S. MacLeod, Joseph Kirma, Margaret M. Lowe, Yanyun Jiang, Syed Monem Rizvi, Rachael Wasikowski, Johann E. Gudjonsson, Fei Wen, Chang Zeng, Michael Rosenblum, Feiyang Ma, H.H. van der Zee, Matthew Patrick, Stephan Weidinger, Celine C. Berthier, Enze Xing |
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| Přispěvatelé: | Erasmus MC other, Dermatology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Proteome Plasma Cells Immunology Complement Syk Dermatology Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Agammaglobulinaemia Tyrosine Kinase 2.1 Biological and endogenous factors Medicine Bruton's tyrosine kinase Humans Syk Kinase Hidradenitis suppurativa Gene Regulatory Networks Aetiology Skin B-Lymphocytes B cells biology business.industry Inflammatory and immune system General Medicine medicine.disease Complement system Hidradenitis Suppurativa Infectious Diseases 030104 developmental biology Gene Expression Regulation 030220 oncology & carcinogenesis Case-Control Studies Cancer research biology.protein Tumor necrosis factor alpha Single-Cell Analysis business Transcriptome Tyrosine kinase Biomarkers Signal Transduction Research Article |
| Zdroj: | JCI insight, 5(19):e139930. The American Society for Clinical Investigation JCI Insight JCI Insight, Vol 5, Iss 19 (2020) JCI insight, vol 5, iss 19 |
| ISSN: | 2379-3708 |
| Popis: | Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton’s tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS. B-cells and plasma cells are critical pathogenic cell populations in chronic Hidradenitis Suppurativa and are potential therapeutic targets. |
| Databáze: | OpenAIRE |
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