Exposure to pyrethroids insecticides and serum levels of thyroid-related measures in pregnant women
| Autor: | Miyako Shirakawa, Jun Yoshinaga, Aya Hisada, Yumiko Noda, Jie Zhang, Nobumasa Kato, Takashi Okai, Hiroaki Shiraishi, Kazuhisa Shimodaira |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Insecticides medicine.medical_specialty Thyroxine-Binding Globulin Urinary system Thyroid Gland Thyrotropin Benzoates Biochemistry Cohort Studies chemistry.chemical_compound Japan Thyroid-stimulating hormone Pregnancy Surveys and Questionnaires Internal medicine Pyrethrins parasitic diseases medicine Humans Prospective Studies General Environmental Science Creatinine Pyrethroid Smoking Thyroid Environmental Exposure Environmental exposure medicine.disease Thyroxine Endocrinology medicine.anatomical_structure chemistry Regression Analysis Female Biomarkers Iodine Hormone |
| Zdroj: | Environmental Research. 127:16-21 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/j.envres.2013.10.001 |
| Popis: | Possible association between environmental exposure to pyrethroid insecticides and serum thyroid-related measures was explored in 231 pregnant women of 10-12 gestational weeks recruited at a university hospital in Tokyo during 2009-2011. Serum levels of free thyroxine (fT4), thyroid stimulating hormone (TSH) and thyroid biding globulin (TBG) and urinary pyrethroid insecticide metabolite (3-phenoxybenzoic acid, 3-PBA) were measured. Obstetrical information was obtained from medical records and dietary and lifestyle information was collected by self-administered questionnaire. Geometric mean concentration of creatinine-adjusted urinary 3-PBA was 0.363 (geometric standard deviation: 3.06) μg/g cre, which was consistent with the previously reported levels for non-exposed Japanese adult females. The range of serum fT4, TSH and TBG level was 0.83-3.41 ng/dL, 0.01-27.4 μIU/mL and 16.4-54.4 μg/mL, respectively. Multiple regression analysis was carried out by using either one of serum levels of thyroid-related measures as a dependent variable and urinary 3-PBA as well as other potential covariates (age, pre-pregnancy BMI, parity, urinary iodine, smoking and drinking status) as independent variables: 3-PBA was not found as a significant predictor of serum level of thyroid-related measures. Lack of association may be due to lower pyrethroid insecticide exposure level of the present subjects. Taking the ability of pyrethroid insecticides and their metabolite to bind to nuclear thyroid hormone (TH) receptor, as well as their ability of placental transfer, into consideration, it is warranted to investigate if pyrethroid pesticides do not have any effect on TH actions in fetus brain even though maternal circulating TH level is not affected. |
| Databáze: | OpenAIRE |
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