Transcriptome analysis reveals immune pathways underlying resistance in the common carp Cyprinus carpio against the oomycete Aphanomyces invadans
| Autor: | Ravindra, D. K. Verma, Pieter van West, Chris Hauton, Sergei Shubin, Manoj Kumar Yadav, Vindhya Mohindra, Neeraj Sood, Luca Peruzza, Kenton L. Morgan, Franziska Trusch, Pravata Kumar Pradhan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Fish Proteins Carps Plant disease resistance Aphanomyces Infections 01 natural sciences Common carp Microbiology Cyprinus Aphanomyces invadans Transcriptome 03 medical and health sciences Fish Diseases Immune system Phagocytosis Genetics Animals Immune response Gene 030304 developmental biology Oomycete 0303 health sciences Disease resistance biology Histocompatibility Antigens Class I Head kidney RNA sequencing Chemokines Disease Resistance biology.organism_classification sense organs 010606 plant biology & botany |
| Popis: | Infection with Aphanomyces invadans is a serious fish disease with major global impacts. Despite affecting over 160 fish species, some of the species like the common carp Cyprinus carpio are resistant to A. invadans infection. In the present study, we investigated the transcriptomes of head kidney of common carp experimentally infected with A. invadans. In time course analysis, 5288 genes were found to be differentially expressed (DEGs), of which 731 were involved in 21 immune pathways. The analysis of immune-related DEGs suggested that efficient processing and presentation of A. invadans antigens, enhanced phagocytosis, recognition of pathogen-associated molecular patterns, and increased recruitment of leukocytes to the sites of infection contribute to resistance of common carp against A. invadans. Herein, we provide a systematic understanding of the disease resistance mechanisms in common carp at molecular level as a valuable resource for developing disease management strategies for this devastating fish-pathogenic oomycete. |
| Databáze: | OpenAIRE |
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