Synthesis of Alkylidenecyclopropanes by Palladium-Catalyzed Reaction of Propargyl-Substituted Malonate Esters with Aryl Halides by Anti-carbopalladation Pathway
| Autor: | Hideki Yorimitsu, Koichiro Oshima, Daishi Fujino |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cyclopropanes
chemistry.chemical_classification Double bond Hydrocarbons Halogenated Aryl Halide chemistry.chemical_element General Chemistry Hydrocarbons Aromatic Biochemistry Malonates Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Malonate chemistry Alkynes Propargyl Organic chemistry Stereoselectivity Palladium |
| Zdroj: | ResearcherID |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja203062z |
| Popis: | Palladium-catalyzed arylative cyclization of propargyl-substituted malonate esters with aryl halides offers a stereoselective approach to alkylidenecyclopropanes. The reaction proceeds by an anti-carbopalladation pathway, which guarantees the exclusive stereocontrol of the resulting double bond. The highly strained as well as densely substituted skeletons of the products facilitate further versatile transformations, which underscores the importance of the products as synthetic intermediates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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