Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysis
| Autor: | Sara Kenyon, Jennifer V. Nash, David J. Taylor, Stephanie Winsor, Carolyn E. Hutzal, Haresh Kirpalani, Elaine M. Boyle |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Fetal Membranes Premature Rupture medicine.medical_specialty Pediatrics medicine.drug_class Pregnancy Trimester Third Antibiotics Infant Premature Diseases Placebo Drug Administration Schedule law.invention Young Adult Obstetric Labor Premature Randomized controlled trial Pregnancy Reference Values law Infant Mortality medicine Humans Young adult Probability Randomized Controlled Trials as Topic Antibacterial agent Dose-Response Relationship Drug Obstetrics business.industry Infant Newborn Pregnancy Outcome Obstetrics and Gynecology medicine.disease Anti-Bacterial Agents Treatment Outcome Gestation Female business Premature rupture of membranes Infant Premature Follow-Up Studies |
| Zdroj: | American Journal of Obstetrics and Gynecology. 199:620.e1-620.e8 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2008.07.008 |
| Popis: | We conducted a metaanalysis to determine whether antibiotics prolong pregnancy and reduce neonatal morbidity in preterm premature rupture of membranes (PPROM) and preterm labor (PTL) at 34 weeks or less.Randomized trials comparing antibiotic therapy with placebo in PPROM or PTL at a gestation of 34 weeks or less were retrieved. The primary outcome was time to delivery (latency). Infant outcomes included mortality, infection, neurological abnormality, respiratory disease, and neonatal stay.Antibiotics were associated with prolongation of pregnancy in PPROM (P.01) but not PTL. Clinically diagnosed neonatal infections were reduced in both groups; there was a trend toward reduced culture-positive sepsis in PPROM. Intraventricular hemorrhage (all grades) was reduced in PPROM. Other neonatal outcomes were unaffected by antenatal antibiotics.Antibiotics prolong pregnancy and reduce neonatal morbidity in women with PPROM at a gestation of 34 weeks or less. In PTL at a gestation of 34 weeks or less, there is little evidence of benefit from administration of antibiotics. |
| Databáze: | OpenAIRE |
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