Longitudinal stability of a multimodal visco-elastic polyacrylamide gel phantom for magnetic resonance and ultrasound shear-wave elastography

Autor: Eika Hotta, Mikio Suga, Jeff Kershaw, Masashi Usumura, Riwa Kishimoto, Koki Ishii, Tatsuya Higashi, Takayuki Obata
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Glycerol
Polymers
Acrylic Resins
Biochemistry
Stiffness
Polymerization
030218 nuclear medicine & medical imaging
0302 clinical medicine
Medicine and Health Sciences
Longitudinal Studies
Magnetic Resonance
Materials
Multidisciplinary
medicine.diagnostic_test
Phantoms
Imaging
Viscosity
Liver Diseases
Physics
Monomers
Ultrasound
Magnetism
Chemical Reactions
Viscoelasticity
Condensed Matter Physics
Magnetic Resonance Imaging
Chemistry
Macromolecules
030220 oncology & carcinogenesis
Physical Sciences
Elasticity Imaging Techniques
Liver Fibrosis
Medicine
Elastography
Polyacrylamides
Research Article
Materials science
Science
Materials Science
Material Properties
Gastroenterology and Hepatology
Imaging phantom
03 medical and health sciences
medicine
Mechanical Properties
Shear wave elastography
business.industry
Longitudinal static stability
Biology and Life Sciences
Magnetic resonance imaging
Polymer Chemistry
Elasticity
Magnetic resonance elastography
business
Gels
Biomarkers
Biomedical engineering
Zdroj: PLoS ONE, Vol 16, Iss 5, p e0250667 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: We evaluated the long-term stability of a newly developed viscoelastic phantom made of polyacrylamide (PAAm) gel for magnetic resonance elastography (MRE) and ultrasound-based shear-wave elastography (US SWE). The stiffness of the cylindrical phantom was measured at 0, 13 and 18 months. Storage and loss moduli were measured with MRE, and shear-wave speed (SWS) was measured with US SWE. Long-term stability was evaluated in accordance with the Quantitative Imaging Biomarker Alliance (QIBA) profiles for each modality. The initial storage and loss moduli of the phantom were 5.01±0.22 and 1.11±0.15 respectively, and SWS was 2.57±0.04 m/s. The weight of the phantom decreased by 0.6% over the 18 months. When measured with MRE, the stiffness of the phantom decreased and changes to the storage and loss moduli were -3.0% and -4.6% between 0 and 13 months, and -4.3% and 0.0% between 0 and 18 months. The US measurements found that SWS decreased by 2.4% over the first 13 months and 3.6% at 18 months. These changes were smaller than the tolerances specified in the QIBA profiles, so the viscoelastic PAAm gel phantom fulfilled the condition for long-term stability. This new phantom has the potential to be used as a quality assurance and quality control phantom for MRE and US SWE.
Databáze: OpenAIRE
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