Basal forebrain septal nuclei are enlarged in healthy subjects prior to the development of Alzheimer's disease
Autor: | Wai Tsui, Patrick Harvey, Lidia Glodzik, Xiuyuan Wang, Elizabeth Pirraglia, Jingyun Chen, Tracy Butler, Emily Tanzi, Yi Li, Caroline Silver, Henry Rusinek, Mony J. de Leon, Esther Fischer, Ricardo S. Osorio, Anup Deshpande |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male Risk Aging Pathology medicine.medical_specialty Time Factors Basal Forebrain Nucleus basalis Article 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Neuroplasticity medicine Dementia Humans Cognitive Dysfunction Cholinergic neuron Aged Aged 80 and over Basal forebrain medicine.diagnostic_test business.industry General Neuroscience Septal nuclei Magnetic resonance imaging Organ Size Middle Aged medicine.disease Image Enhancement Magnetic Resonance Imaging Healthy Volunteers 030104 developmental biology medicine.anatomical_structure Biomarker (medicine) Female Septal Nuclei Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Developmental Biology |
Zdroj: | Neurobiology of aging. 65 |
ISSN: | 1558-1497 |
Popis: | Alzheimer's disease (AD) is known to be associated with loss of cholinergic neurons in the nucleus basalis of Meynert, located in the posterior basal forebrain. Structural changes of septal nuclei, located in the anterior basal forebrain, have not been well studied in AD. Using a validated algorithm, we manually traced septal nuclei on high-resolution coronal magnetic resonance imaging (MRI) in 40 subjects with mild cognitive impairment (MCI) or AD, 89 healthy controls, and 18 subjects who were cognitively normal at the time of MRI but went on to develop AD an average of 2.8 years later. We found that cognitively normal subjects destined to develop AD in the future had enlarged septal nuclei as compared to both healthy controls and patients with current MCI or AD. To our knowledge, this is the first time a brain structure has been found to be enlarged in association with risk of AD. Further research is needed to determine if septal enlargement reflects neuroplastic compensation, amyloid deposition, inflammation, or another process and to determine whether it can serve as an early MRI biomarker of AD. |
Databáze: | OpenAIRE |
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