Genome sequencing of SARS-CoV-2 reveals the prevalence of variant B 1.1.7 in Egypt

Autor: Mohamed G. Seadawy, Ahmed F. Gad, Sabah A. Abo-Elmaaty, Mervat G. Hassan
Rok vydání: 2021
Předmět:
Microbiology (medical)
VOI
Variant of interest
Genome
Viral
Antibodies
Viral
Microbiology
Article
WHO
World health organization
EUS
Emergency Use Authorization
BLAST
Basic Local Alignment Search Tool
NSP1-16
Non-structural proteins 1 1-6
Genetics
Prevalence
Humans
NTD
N-terminal domain
Molecular Biology
BWA
Burrows-Wheeler Aligner software
Ecology
Evolution
Behavior and Systematics
Phylogeny
COVID-19 Serotherapy
Whole Genome Sequencing
SARS-CoV-2
B 1.1.7
Immunization
Passive
VOC
Variant of Concern
virus diseases
Antibodies
Monoclonal
COVID-19
RBM
Receptor binding motif
Antibodies
Neutralizing
Infectious Diseases
Alpha variant
COVID-19
Coronavirus Disease 2019
Epidemiological Monitoring
ORF
Open reading frame
Egypt
Public Health
SARS-CoV2
Severe Acute Respiratory Syndrome Coronavirus 2
Ct
Cycle thresholds
Zdroj: Infection, Genetics and Evolution
ISSN: 1567-7257
Popis: Recently, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in Coronavirus Disease 2019 (COVID-19) outbreak. A new SARS-CoV-2 strain is expected to emerge in late 2020, including B.1.1.7. The high transmission rate of SARS-CoV-2 B.1.1.7 has raised public health concerns in several countries. Hence, in this study, we assessed the sequencing of SARS-COV2 to reveals the prevalence of the SARS-CoV-2 Alpha variant (B 1.1.7) in Egypt. We found that the viral transmission of the alpha variant is expanding. Moreover, based on hospitalizations and case fatality rates, there is a potential for increasing severity. There was no effect on susceptibility to Emergency Use Authorization monoclonal antibody treatments. However, there was minimal impact on neutralization by convalescent and post-vaccination sera. Samples have been clustered into the 20D sub clade for the majority of them. The eight samples shown in our study are considered the first recorded samples with the Alpha variant in Egypt. Therefore, The Egyptian government, represented by the Ministry of Health, must take all measures to examine the compatibility of the currently used vaccines with this new strain and the feasibility of the treatment protocol presently used with such strains developed in the Arab Republic of Egypt.
Databáze: OpenAIRE
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