Fourteen short tandem repeat loci Y chromosome haplotypes: Genetic analysis in populations from northern Brazil
| Autor: | Elzemar Martins Ribeiro-Rodrigues, Sidney Santos, Ândrea Ribeiro-dos-Santos, Teresinha de Jesus Brabo Ferreira Palha |
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| Rok vydání: | 2011 |
| Předmět: |
Genetic Markers
Male Population Biology Genetic analysis Analysis of molecular variance Pathology and Forensic Medicine Genetic variation Genetics Humans education education.field_of_study Genetic diversity Analysis of Variance Chromosomes Human Y Haplotype Genetic Variation DNA Fingerprinting Genetics Population Genetic distance Haplotypes Genetic marker Multiplex Polymerase Chain Reaction Brazil Microsatellite Repeats |
| Zdroj: | Forensic science international. Genetics. 6(3) |
| ISSN: | 1878-0326 |
| Popis: | Fourteen Y-STR loci (DYS458, DYS439, Y-GATA H4, DYS576, DYS447, DYS460, DYS456, YGATA A10, DYS437, DYS449, DYS570, DYS635 or Y-GATA C4, DYS448 and DYS438) were analysed in 873 males from eight northern Brazil populations: Belem (N=400), Santarem (N=69), Manaus (N=75), Macapa (N=65), Palmas (N=30), Rio Branco (N=32), Porto Velho (N=135) and Boa Vista (N=67). A total of 871 different haplotypes were identified, of which 869 were unique. The panel's estimated total haplotype diversity (HD) is 0.9988, and its discrimination capacity (DC) is 0.9980. The lowest estimates of genetic diversity correspond to markers Y-GATA H4 (0.550) and DYS460 (0.581), and the greatest (above 0.700) to markers DYS458, DYS576, DYS447, YS449, DYS570 and DYS635. The genetic parameters obtained were higher for the 14-Y-STR panel than that for the minimum haplotype set (HD=0.9969; DC=0.76) and the parameters were similar to those obtained with the panel of 17 YSTR of YHRD (HD=0.9987; DC=0. 9870). The analysis of molecular variance (AMOVA) indicated that most of the genetic variance is found within populations and a smaller, but significant part, is found among populations (R(ST)=0.027, p value=0.009). The data when compared with those from African, Amerindian and European populations have shown no significant genetic distance between northern Brazil populations and Europeans, but there is a significant genetic distance when compared to Africans and Amerindians. The discrimination capacity of the markers shows a high potential for forensic analysis. |
| Databáze: | OpenAIRE |
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