Toll-like receptor 4 (TLR4) gene polymorphisms in celiac disease
| Autor: | Izortze Santin, Ainara Castellanos-Rubio, Idoia Hualde, Jose Ramon Bilbao, Juan Carlos Vitoria, Luis Castaño |
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| Rok vydání: | 2007 |
| Předmět: |
Genotype
Immunology Single-nucleotide polymorphism Disease Biology Biochemistry Polymorphism Single Nucleotide Antigen Gene Frequency Genetics medicine Immunology and Allergy Humans Family Genetic Predisposition to Disease Allele Toll-like receptor Haplotype General Medicine medicine.disease Ulcerative colitis Toll-Like Receptor 4 Celiac Disease Amino Acid Substitution Haplotypes Spain Case-Control Studies |
| Zdroj: | Tissue antigens. 70(6) |
| ISSN: | 0001-2815 |
| Popis: | Toll-like receptors (TLRs) participate in the first line of immune defense through antigen pattern recognition, and ligands include exogenous and host-derived molecules. Coding variants in TLR4 have been associated with autoimmune diseases like ulcerative colitis, Crohn’s disease, and rheumatoid arthritis. Our aim was to determine whether these polymorphisms are associated with celiac disease (CD). Two coding single nucleotide polymorphisms of TLR4 (Asp299Gly and Thr399Ile) were genotyped in 95 family trios with CD as well as in 186 patients and 186 unrelated controls. There were no differences in allele, genotype or haplotype distribution, or transmission between patient and control groups. Our results do not support association of these TLR4 variants with CD. |
| Databáze: | OpenAIRE |
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