Efficacy of simultaneous aerobic exercise and cognitive training in subjective cognitive decline: study protocol for randomized controlled trial of the Exergames Study
| Autor: | Fang Yu, Dereck Salisbury, Tom Plocher |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Psychological intervention Medicine (miscellaneous) law.invention Study Protocol Cognition Physical medicine and rehabilitation Randomized controlled trial Alzheimer Disease law Humans Medicine Aerobic exercise Cognitive Dysfunction Pharmacology (medical) Cognitive decline Exercise Aged Randomized Controlled Trials as Topic lcsh:R5-920 business.industry Attentional control Cognitive training Exercise Therapy Treatment Outcome Subjective cognitive decline Analysis of variance lcsh:Medicine (General) business Alzheimer’s disease |
| Zdroj: | Trials, Vol 22, Iss 1, Pp 1-10 (2021) Trials |
| ISSN: | 1745-6215 0431-1736 |
| Popis: | BackgroundSubjective cognitive decline (SCD) is an early manifestation of Alzheimer’s disease (AD) and offers a therapeutic window where interventions have strong potential to prevent or delay the progression of AD. Aerobic exercise and cognitive training represent two promising interventions for AD prevention, but their synergistic effect has yet to be assessed in persons with SCD.Methods/designThe purpose of this single-blinded, 3-parallel group randomized controlled trial is to test the synergistic efficacy of an exergame intervention (simultaneous moderate-intensity aerobic cycling and cognitive training) on cognition and aerobic fitness in community-dwelling older adults with SCD. The Exergames Study will randomize 96 participants on a 2:1:1 allocation ratio to 3-month exergame, cycling only, or attention control (stretching). Primary outcomes include global cognition and aerobic fitness, which will be assessed at baseline and after 3 months. The specific aims of the Exergames Study are to (1) determine the efficacy of the exergame in older adults with SCD and (2) assess the distraction effect of exergame on aerobic fitness. Data will be analyzed using ANOVA following intention-to-treat.DiscussionThis study will test the synergistic effects of exergame on cognition and aerobic fitness. It has the potential to advance prevention research for AD by providing effect-size estimates for future trials.Trial registrationClinicalTrials.govNCT04311736. Registered on 17 March 2020. |
| Databáze: | OpenAIRE |
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