Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons

Autor:	Linda Maria Requie, Marta Gómez-Gonzalo, Michele Speggiorin, Francesca Managò, Marcello Melone, Mauro Congiu, Angela Chiavegato, Annamaria Lia, Micaela Zonta, Gabriele Losi, Vanessa Jorge Henriques, Arianna Pugliese, Giada Pacinelli, Giovanni Marsicano, Francesco Papaleo, Anna Lisa Muntoni, Fiorenzo Conti, Giorgio Carmignoto
Rok vydání:	2022
Předmět:	Mice Receptors Dopamine D2 Dopaminergic Neurons Astrocytes Dopamine General Neuroscience Ventral Tegmental Area Animals
Zdroj:	Nature Neuroscience. 25:1639-1650
ISSN:	1546-1726 1097-6256
Popis:	The plasticity of glutamatergic transmission in the ventral tegmental area (VTA) represents a fundamental mechanism in the modulation of dopamine neuron burst firing and phasic dopamine release at target regions. These processes encode basic behavioral responses, including locomotor activity, learning and motivated behaviors. Here we describe a hitherto unidentified mechanism of long-term synaptic plasticity in mouse VTA. We found that the burst firing in individual dopamine neurons induces a long-lasting potentiation of excitatory synapses on adjacent dopamine neurons that crucially depends on Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02090c013f5c7f44c8f704f52311840 https://doi.org/10.1038/s41593-022-01193-4 Zobrazit plný text záznamu Full text from SpringerLink