Fetal phenytoin exposure, hypoplastic nails, and jitteriness
| Autor: | S W D'Souza, D Donnai, G Mawer, I G Robertson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Phenytoin
Pediatrics medicine.medical_specialty Poison control Nails Malformed Epilepsy Fetus Pregnancy medicine Humans Prospective Studies Prospective cohort study Maternal-Fetal Exchange business.industry Infant Newborn Abnormalities Drug-Induced medicine.disease Hypoplasia Pregnancy Complications Nail disease Pediatrics Perinatology and Child Health Female business Complication medicine.drug Akathisia Drug-Induced Research Article |
| Zdroj: | Archives of disease in childhood. 66(3) |
| ISSN: | 1468-2044 |
| Popis: | In a prospective study infants born to mothers with epilepsy (n = 61) were found to have an unexpectedly high incidence of congenital anomalies (26/61, 43%) and neonatal conditions (26/61, 43%) compared with controls (0/62, and 6/62, 10%, respectively). There were two neonatal deaths in the study group but none among the controls. Hypoplasia of the finger or toenails was a common congenital anomaly in those infants whose mothers had received phenytoin alone or in combination with other anticonvulsant drugs (11 of 40, 28%). The mean serum phenytoin concentration was higher among mothers of infants with hypoplastic nails than among those with normal nails. Jitteriness was a common neonatal condition affecting infants of epileptic mothers (11 of 61, 18%) but not controls The mean cord serum phenytoin concentrations were similar among jittery and non-jittery infants. At follow up (after excluding one infant with Down's syndrome from the study group) the infants seemed to have developed normally, though one had serious learning difficulties at school. We suggest that hypoplasia of the nails is related to high maternal serum concentrations of phenytoin, and though 18% of infants born to epileptic mothers were jittery compared with no control infants this may not be the result of withdrawal of the drug in all cases. |
| Databáze: | OpenAIRE |
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