Pancreatic enhancement and pulse sequence analysis using low-dose mangafodipir trisodium
| Autor: | Wolfgang Schima, William W. Mayo-Smith, G. J. Slater, Sanjay Saini, E G McFarland |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pancreatic disease Contrast Media medicine Mangafodipir Humans Radiology Nuclear Medicine and imaging Pancreas Edetic Acid Aged Manganese medicine.diagnostic_test business.industry Pulse (signal processing) Low dose Mangafodipir trisodium Pulse sequence Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Pancreatic Neoplasms medicine.anatomical_structure Pyridoxal Phosphate Female Nuclear medicine business medicine.drug |
| Zdroj: | AJR. American journal of roentgenology. 170(3) |
| ISSN: | 0361-803X |
| Popis: | The purpose of this study was to evaluate pancreatic enhancement with low-dose mangafodipir trisodium (5 mumol/kg) using three different T1-weighted pulse sequences.Fifteen patients, six of whom had proven focal pancreatic tumors, underwent T1-weighted gradient-recalled echo imaging, spin-echo imaging, and fat-suppressed spin-echo imaging before and 30 min after injection of 5 mumol/kg of mangafodipir trisodium. Region-of-interest measurements were obtained in the pancreas before and after contrast enhancement. Signal-to-noise ratios were calculated in all 15 patients. Contrast-to-noise ratios were calculated in the six patients with pancreatic tumors.The signal-to-noise ratios of the pancreas increased after injection of mangafodipir trisodium on all three T1-weighted pulse sequences (p.001). Enhanced fat-suppressed sequences (29 +/- 7.7) and gradient-recalled echo sequences (29 +/- 9.6) had the highest signal-to-noise ratios. Contrast-to-noise ratios between normal pancreatic tissue and pancreatic tumor also increased after contrast administration (p.05) and were highest on the fat-suppressed (-9.6 +/- 4.0) pulse sequence.Mangafodipir trisodium produced marked pancreatic enhancement at a dose of 5 mumol/kg for all three T1-weighted pulse sequences. The enhanced T1-weighted spin-echo fat-suppressed sequence showed the highest signal-to-noise and contrast-to-noise ratios. |
| Databáze: | OpenAIRE |
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