Serum MMP-9 Diagnostics, Prognostics, and Activation in Acute Coronary Syndrome and Its Recurrence
| Autor: | Pirkko J. Pussinen, Timo Sorsa, Laura Lahdentausta, Alina Winkelmann, Erkki Pesonen, Taina Tervahartiala, Jaakko Leskelä |
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| Přispěvatelé: | University of Helsinki, Research Programmes Unit, University of Helsinki, Department of Oral and Maxillofacial Diseases, University of Helsinki, Hammaslääketieteen laitos (-2009) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Time Factors Pharmaceutical Science Infarction Endogeny 030204 cardiovascular system & hematology Matrix metalloproteinase Serum biomarker Gastroenterology Coronary artery disease 0302 clinical medicine Recurrence Genetics (clinical) Plaque rupture Middle Aged Prognosis 3. Good health Cardiovascular diseases Matrix Metalloproteinase 9 Molecular Medicine Female Original Article medicine.symptom Cardiology and Cardiovascular Medicine medicine.medical_specialty Acute coronary syndrome education Gelatin Zymography Inflammation 3121 Internal medicine 03 medical and health sciences Predictive Value of Tests Internal medicine Genetics medicine Humans Acute Coronary Syndrome Aged Tissue Inhibitor of Metalloproteinase-1 business.industry medicine.disease Atherosclerosis 313 Dentistry Enzyme Activation 030104 developmental biology Case-Control Studies business Biomarkers |
| Zdroj: | Journal of Cardiovascular Translational Research |
| ISSN: | 1937-5395 |
| Popis: | Matrix metalloproteinase (MMP)-9 is crucial in atherosclerotic plaque rupture and tissue remodeling after a cardiac event. The balance between MMP-9 and endogenous inhibitor, tissue inhibitors of matrix metalloproteinase 1 (TIMP-1), is important in acute coronary syndrome (ACS). This is an age- and gender-matched case-control study of ACS (N = 669). Patients (45.7%) were resampled after recovery, and all were followed up for 6 years. The molecular forms of MMP-9 were investigated by gelatin zymography. Diagnostically, MMP-9 and the MMP-9/TIMP-1 molar ratio were associated with ACS (OR 5.81, 95% CI 2.65–12.76, and 4.96, 2.37–10.38). The MMP-9 concentrations decreased 49% during recovery (p |
| Databáze: | OpenAIRE |
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