Genome‐wide association study and genomic evaluation of feed efficiency traits in Japanese Black cattle using single‐step genomic best linear unbiased prediction method
| Autor: | Yoshinobu Uemoto, Masahiro Satoh, Masayuki Takeda, Kazuhito Kurogi, Keiichi Inoue, Takanori Yasumori, Atushi Ogino, Takayoshi Nozaki |
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| Rok vydání: | 2019 |
| Předmět: |
Candidate gene
Population Genome-wide association study Computational biology Biology Best linear unbiased prediction Phosphatidylinositols Weight Gain Feed conversion ratio Eating 03 medical and health sciences Quantitative Trait Heritable Animals Genetic Testing education 030304 developmental biology Genetic association 0303 health sciences education.field_of_study Genome 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine Animal Feed 040201 dairy & animal science Genetic architecture Smell Animal Nutritional Physiological Phenomena Cattle Residual feed intake General Agricultural and Biological Sciences Genome-Wide Association Study Signal Transduction |
| Zdroj: | Animal Science Journal. 91 |
| ISSN: | 1740-0929 1344-3941 |
| DOI: | 10.1111/asj.13316 |
| Popis: | The objectives of this study were to better understand the genetic architecture and the possibility of genomic evaluation for feed efficiency traits by (i) performing genome-wide association studies (GWAS), and (ii) assessing the accuracy of genomic evaluation for feed efficiency traits, using single-step genomic best linear unbiased prediction (ssGBLUP)-based methods. The analyses were performed in residual feed intake (RFI), residual body weight gain (RG), and residual intake and body weight gain (RIG) during three different fattening periods. The phenotypes from 4,578 Japanese Black steers, which were progenies of 362 progeny-tested bulls and the genotypes from the bulls were used in this study. The results of GWAS showed that a total of 16, 8, and 12 gene ontology terms were related to RFI, RG, and RIG, respectively, and the candidate genes identified in RFI and RG were involved in olfactory transduction and the phosphatidylinositol signaling system, respectively. The realized reliabilities of genomic estimated breeding values were low to moderate in the feed efficiency traits. In conclusion, ssGBLUP-based method can lead to understand some biological functions related to feed efficiency traits, even with small population with genotypes, however, an alternative strategy will be needed to enhance the reliability of genomic evaluation. |
| Databáze: | OpenAIRE |
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