Functionalized Carbon Nanotube-Embedded Poly(vinyl alcohol) Microspheres for Efficient Removal of Tumor Necrosis Factor-α
Autor: | Chunran Li, Lichun Wang, Wenyan Han, Jian Chen, Zhuang Liu, Tingting Wang, Wenzhong Li, Yamin Chai, Lailiang Ou |
---|---|
Rok vydání: | 2021 |
Předmět: |
Vinyl alcohol
Scanning electron microscope 0206 medical engineering Composite number Biomedical Engineering chemistry.chemical_element 02 engineering and technology Carbon nanotube law.invention Biomaterials chemistry.chemical_compound Adsorption law Animals Nanocomposite Nanotubes Carbon Tumor Necrosis Factor-alpha 021001 nanoscience & nanotechnology 020601 biomedical engineering Microspheres Rats chemistry Polyvinyl Alcohol Tumor necrosis factor alpha 0210 nano-technology Carbon Nuclear chemistry |
Zdroj: | ACS biomaterials scienceengineering. 6(8) |
ISSN: | 2373-9878 |
Popis: | Tumor necrosis factor (TNF)-α has an important role in the pathogenesis of autoimmune and inflammatory diseases such as rheumatoid and septic arthritis. Removal of excess tumor necrosis factor-α (TNF-α) is a promising treatment. In this study, a series of functionalized carbon nanotube-embedded poly(vinyl alcohol) (PVA) nanocomposite adsorbents were prepared for TNF-α removal for the first time. The resulting nanocomposites were characterized by scanning electron microscopy and Raman spectroscopy, which demonstrated that carbon nanotubes were well-dispersed on the surface of PVA macroporous microspheres. Adsorption tests showed that the carboxylated carbon nanotube-embedded composite microspheres (PVA/MWCNTs-COOH) possessed much better adsorption capacity for TNF-α in both simulated serum solution and rat plasma compared to the aminated (PVA/MWCNTs-NH2) and raw carbon nanotube-embedded microspheres (PVA/MWCNTs-raw). In addition, the effects on hemolytic activity, the anticoagulant property, and the components of blood were negligible, indicating the excellent blood compatibility of composite beads. Our findings suggest that the carboxylated carbon nanotube-embedded composite microspheres may be potentially useful for the treatment of autoimmune and inflammatory diseases by removing TNF-α from the blood. |
Databáze: | OpenAIRE |
Externí odkaz: |