Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease?
| Autor: | Melina Da Silva Bernardes, Carmen Lucia Antão Paiva, Eduardo Ribeiro Paradela, Regina Maria Papais Alvarenga, Marcos Papais Alvarenga, Fernanda Ferreira Chaves da Costa Pereira, Claudia Cristina Ferreira Vasconcelos |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Multiple Sclerosis Extended haplotype Immunology Disease 03 medical and health sciences 0302 clinical medicine medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele HLA-DRB1 HLA-DR Serological Subtypes business.industry Multiple sclerosis HLA-DR15 Middle Aged medicine.disease Cross-Sectional Studies 030104 developmental biology Neurology Female Brazilian population Neurology (clinical) Genetic risk factor business Brazil 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimmunology. 330:74-80 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2019.02.004 |
| Popis: | The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population.Association analyses between DR15 and the clinical and demographic variables were made.We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P .00001). DR15 was significantly associated to a foreign ancestor background (P = .029) and later age of onset (P = .018). |
| Databáze: | OpenAIRE |
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