Anti-caries evaluation of a nano-hydroxyapatite dental lotion for use after toothbrushing: An in situ study
| Autor: | Dina Ossama Alshareif, Marina Adel Shehata, Ariana Bagheri, Veronica Evans, Azadeh Abdollahi, Bennett T. Amaechi, Patrícia Paula de Carvalho Sampaio Lima, Parisa Samadi Kalkhorani, L O Okoye, Parveez Ahamed Abdul Azees |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Toothbrushing Molar business.product_category Dentistry Dental Caries Placebo Fluorides stomatognathic system Humans Medicine General Dentistry Toothpaste Enamel paint business.industry Cariostatic Agents Demineralization stomatognathic diseases Durapatite Nano hydroxyapatite Tooth Remineralization visual_art Lotion visual_art.visual_art_medium business Toothpastes In situ study |
| Zdroj: | Journal of Dentistry. 115:103863 |
| ISSN: | 0300-5712 |
| DOI: | 10.1016/j.jdent.2021.103863 |
| Popis: | The aim of this randomized, double-blind, two-arm crossover in situ study was to investigate whether nano-hydroxyapatite (nanoHAP) dental lotion (Apagard Deep Care) applied immediately after tooth-brushing with nanoHAP toothpaste (Apagard M-plus) enhances the remineralization promotion and the demineralization inhibition efficacies of nanoHAP toothpastes.64 sound enamel blocks and 64 blocks bearing artificially-produced initial caries were produced from human permanent molar teeth. During each treatment period, lasting 14 days per arm, two blocks, one sound and one lesion-bearing, were exposed to either 5% nanoHAP-containing or placebo dental lotion after tooth-brushing with 5% nanoHAP toothpaste, via an intra-oral appliance worn by 30 adults in each of the study groups. Baseline and post-test mineral loss were quantified using transverse microradiography (TMR). One-sided t-test of one group mean was used for intragroup comparison, while two-sided t-test of two independent means was used to compare the two dental lotions.Pairwise comparison (baseline vs. post-test) indicated significant (p.001) remineralization by nanoHAP toothpaste in both groups. However, when compared against each other, there was a significantly (p.001) greater percentage of remineralization with nanoHAP lotion [58.4(±1.8)%] than with placebo lotion [37.7(±2.2)%]. TMR examination showed absolute demineralization inhibition in sound enamel blocks exposed to either lotions.Toothpaste containing 5% nanoHAP effectively remineralized initial caries and inhibited demineralization of healthy enamel; however, the application of a dental lotion containing 5% nanoHAP after brushing resulted in superior remineralization compared to a placebo lotion.Dental lotion containing 5% nanohydroxyapatite used immediately after toothbrushing with 5% nanohydroxyapatite toothpaste can serve as an adjunct to enhance the clinical benefits of the toothpaste. |
| Databáze: | OpenAIRE |
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