Radiation-induced lung injury: impact on macrophage dysregulation and lipid alteration – a review
| Autor: | Raviraj R, Zhao W, Nagarajan D, S N Sg |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lung Neoplasms Pulmonary Fibrosis Immunology Lung injury Nitric Oxide Toxicology 03 medical and health sciences 0302 clinical medicine Fibrosis Macrophages Alveolar Pulmonary fibrosis medicine Animals Humans Immunology and Allergy Macrophage Lung cancer Pharmacology Radiotherapy business.industry Cancer General Medicine Lipid Metabolism medicine.disease M2 Macrophage Pulmonary Alveoli Radiation Pneumonitis 030104 developmental biology Radiation-induced lung injury 030220 oncology & carcinogenesis Cancer research Cytokines business |
| Zdroj: | Immunopharmacology and Immunotoxicology. 41:370-379 |
| ISSN: | 1532-2513 0892-3973 |
| DOI: | 10.1080/08923973.2018.1533025 |
| Popis: | Lung cancer continues to be the leading cause of cancer deaths and more than one million lung cancer patients will die every year worldwide. Radiotherapy (RT) plays an important role in lung cancer treatment, but the side effects of RT are pneumonitis and pulmonary fibrosis. RT-induced lung injury causes damage to alveolar-epithelial cells and vascular endothelial cells. Macrophages play an important role in the development of pulmonary fibrosis despite its role in immune response. These injury activated macrophages develop into classically activated M1 macrophage or alternative activated M2 macrophage. It secretes cytokines, interleukins, interferons, and nitric oxide. Several pro-inflammatory lipids and pro-apoptotic proteins cause lipotoxicity such as LDL, FC, DAG, and FFA. The overall findings in this review conclude the importance of macrophages in inducing toxic/inflammatory effects during RT of lung cancer, which is clinically vital to treat the radiation-induced fibrosis. |
| Databáze: | OpenAIRE |
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