The use of proteomic technologies in breast cancer research
| Autor: | M G Mazur, T V Pyatchanina |
|---|---|
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Tumor microenvironment business.industry Proteomic Profiling Reviews medicine.disease Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Stroma Tumor progression 030220 oncology & carcinogenesis Internal medicine medicine business |
| Zdroj: | Scopus-Elsevier |
| Popis: | The main findings in the field of breast cancer proteomic research as well as modern strategies, technologies and methods of validation are reviewed. A special attention is focused on validated proteomic biomarkers of breast cancer. The data on proteomic profiling of stroma, tumor microenvironment, involvement of proteins in tumor progression, invasion and metastasis, and mechanisms of action of new generation drugs, are analyzed. The results of proteomic analysis are of high clinical importance and significantly improve tumor molecular profiling, stratification of patients, screening, diagnostics, and therapy of breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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