No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer’s Disease
| Autor: | Miwa Komatsu, Tohru Nakamura, Nobuto Shibata, Ryo Hanzawa, Heii Arai, Katrin Thompson, Maiko Kitazawa, Mayu Takeda, Tohru Ohnuma, Hiromi Shimazaki, Yuto Takebayashi, Ryoko Higashiyama |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genetics
Apolipoprotein E education.field_of_study Cognitive Neuroscience Age of onset Haplotype Population Single-nucleotide polymorphism Alzheimer's disease lcsh:Geriatrics Biology lcsh:RC346-429 lcsh:RC952-954.6 Psychiatry and Mental health Immunology SNP PGBD1 Original Research Article Polymorphism Allele education Alzheimer’s disease lcsh:Neurology. Diseases of the nervous system Genetic association |
| Zdroj: | Dementia and Geriatric Cognitive Disorders Extra, Vol 2, Iss 1, Pp 496-502 (2012) Dementia and Geriatric Cognitive Disorders EXTRA |
| ISSN: | 1664-5464 |
| DOI: | 10.1159/000345085 |
| Popis: | Background/Aims: PiggyBac transposable element derived 1 (PGBD1) encodes a molecule involved in epigenetic mechanisms that have been implicated in Alzheimer’s disease (AD), and recent genome-wide association studies and meta-analyses have indicated that a single nucleotide polymorphism (SNP), rs3800324, in PGBD1 could be associated with AD and the age of onset. However, no Japanese patients were examined in these studies. The aim of the present study was to replicate the previous finding in Japanese AD cases. Methods: We performed a case-control study (211 cases and 156 controls) to investigate the association between PGBD1 and Japanese AD using 4 tag SNPs including rs3800324. Results: Single SNP and haplotype analysis showed no association between AD and age of onset, whereas genotypic and allelic frequencies of the ε4 of apolipoprotein E (APOE) showed an association with AD as expected. Conclusion: In Japanese AD, we observed no influence of PGBD1, as either a risk factor or a modifier, even though APOE was associated with AD in this population. |
| Databáze: | OpenAIRE |
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