High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population
| Autor: | Afef Achouri Rassas, Aroua Cherif, Amel Mrabet, Sondes Hadj Fredj, Nadia Anane, Hela Mrabet Khiari, Nouria Oudiaa Zakraoui, Safa Sahnoun, Taieb Messaoud, H. Batti, Nadia Ben Ali |
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| Rok vydání: | 2011 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Tunisia Genotype Apolipoprotein E4 Dermatology Gene Frequency Alzheimer Disease Internal medicine medicine Humans Risk factor Allele Allele frequency Genotyping Alleles Genetic Association Studies Aged Genetics Aged 80 and over General Medicine Odds ratio Middle Aged Psychiatry and Mental health Case-Control Studies Female Neurology (clinical) Restriction fragment length polymorphism Psychology |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 33(1) |
| ISSN: | 1590-3478 |
| Popis: | The goal of the study was to examine the Apolipoprotein E (APOE) genotypes in a Tunisian sample of patients with Alzheimer disease (AD) and normal controls, and to compare the results with the findings from the literature. A hospital-based case–control study of two groups (58 patients with AD, 71 controls) was conducted. Patients received a detailed clinical history, neurological examination, neuropsychological testing and brain imaging. A neurological examination and the Arabic version of the Mini-Mental State Examination were made for controls. Genotyping was performed using the PCR restriction fragment length polymorphism (PCR–RFLP) method. There were no statistical differences in age (p = 0.05) and gender (p = 0.046) between the two groups. The APOE e4/4 genotype was over represented in the AD group in comparison with the controls (13.3 vs. 2.8%). A significant increased risk of AD among APOE e4 allele carriers was observed. The odds ratio for the association of AD patients with homozygous and heterozygous e4 allele was, respectively, 5.40 (1.35–21.48) and 2.90 (1.27–6.62). Our results in addition to previously published genetic studies suggest that AD disease is multifactor in origin. Ethnicity, genetic and environmental factors contribute to AD risk in different ethnic groups. |
| Databáze: | OpenAIRE |
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