Prognostic Significance of NT-proBNP Levels in Patients over 65 Presenting Acute Myocardial Infarction Treated Invasively or Conservatively
| Autor: | Agata Popielarz-Grygalewicz, Wojciech Drewniak, Agnieszka Król-Jaskulska, Joanna Kotlarska, Wojciech Szybka, Dariusz Bielecki, Marek Dąbrowski, Aleksandra Konwicka, Michal Malinowski |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Article Subject medicine.medical_treatment Myocardial Infarction lcsh:Medicine Kaplan-Meier Estimate General Biochemistry Genetics and Molecular Biology Superior left Angioplasty Internal medicine Natriuretic Peptide Brain medicine Humans In patient Myocardial infarction cardiovascular diseases Aged Aged 80 and over Ejection fraction General Immunology and Microbiology Ventricular function business.industry lcsh:R General Medicine Prognosis medicine.disease Peptide Fragments Surgery Heart failure Clinical Study Cardiology Female business |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Objectives. Assessment of prognostic significance of NT-proBNP level and the effects of invasive (I) and conservative (C) treatment of acute myocardial infarction (AMI) in patients over 65.Materials and Methods. One-year survival was assessed in 286 consecutive patients with AMI aged 65–100 (79 ± 8) subjected to I or C treatment (136 and 150 individuals), respectively.Results. 245 (85%) patients survived in-hospital stay: 124 (91.1%) received I treatment and 121 (80.6%) received C treatment. Heart failure (HF) was diagnosed in 30 patients receiving I treatment (22.6%) and in 71 subjected to C treatment (47.3%),p< 0,0001. NT-proBNP levels in the latter group were significantly higher than in the 185 patients without HF (12311 ± 13560 pg/mL versus 4773 ± 8807 pg/mL,p< 0.0001). NT-proBNP levels after coronary angioplasty were lower than in patients receiving C treatment (5922 ± 10250 pg/mL versus 8718 ± 12024 pg/mL,p= 0.0002). Left ventricular ejection fraction was significantly higher in I patients than in C patients (47 ± 13% versus 42 ± 11.6%,p= 0.004). During the one-year follow-up, 82.3% of I patients and 61.2% of the C patients survived (p< 0.0003). There was a significantly lower probability of death at NT-proBNP below 8548.5 pg/mL.Conclusions. The NT-proBNP level in the first day of AMI is a good prognosticator. One-year follow-up prognosis for patients who received I treatment in the AMI is better than that for C patients. I patients exhibit superior left ventricular function after angioplasty and in the follow-up. |
| Databáze: | OpenAIRE |
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