Hibernation-Induction Trigger. I. Opioid-like Effects of Prairie Dog Plasma Albumin on Induced Contractility of Guinea Pig Ileum
| Autor: | Peter R. Oeltgen, H.J Harlow, Evans C. Bailey, N.D Horton, David S. Bruce, S.K Crane |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Guinea Pigs Clinical Biochemistry Serum albumin Myenteric Plexus Ileum Prairie dog In Vitro Techniques Toxicology Biochemistry Contractility Behavioral Neuroscience Species Specificity Hibernation Internal medicine biology.animal medicine Animals Potency Opioid peptide Serum Albumin Biological Psychiatry Pharmacology Dose-Response Relationship Drug biology Albumin Sciuridae Muscle Smooth Endocrinology medicine.anatomical_structure Opioid Receptors Opioid biology.protein Muscle Contraction medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 58:621-625 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(97)00063-4 |
| Popis: | Studies have shown that plasma albumin fractions (PAFs) from hibernating mammals can inhibit induced contractility of the guinea pig ileum similarly to morphine. This study examined PAFs from two species of prairie dogs, one that undergoes natural seasonal hibernation (white-tailed, WT) and one that does not but can be induced to hibernate (black-tailed, BT). Dose-response curves of lyophilized PAF yielded IC50 values (mg) of 20.23 for summer WT, 15.53 for hibernating WT, 15.45 for summer BT, and 13.16 for winter-active BT. Winter samples from both species have IC50s lower than samples from summer animals, indicating greater potency of winter PAFs in suppressing guinea pig ileum contractility and therefore the presence of more opioid ligands in winter prairie dog plasma. Studies to elucidate receptor selectivity of PAF continue. |
| Databáze: | OpenAIRE |
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