Seroprevalence of hepatitis B virus and hepatitis C virus infection among Malaysian population
| Autor: | Nor Asiah Muhamad, Rozainanee Mohd Zain, Rimah Melati Ab Ghani, Tahir Aris, Hasmah Mohamad Haris, Nazihah Abd Jalal, Nor Azila Muhammad Azami, Mohd Shaharom Abdullah, Eida Nurhadzira Muhammad, Muhammad Radzi Abu Hassan, Norliza Ismail, Azwa Shawani Kamalul Arifin, Mohd Arman Kamaruddin, Mohd Hatta Abdul Mutalip, Noraidatulakma Abdullah, Raihannah Othman, Rahman Jamal, Nurul Ain Mhd Yusuf |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male HBsAg Molecular biology Hepatitis C virus Immunology Population Diseases medicine.disease_cause Article 03 medical and health sciences Medical research 0302 clinical medicine Seroepidemiologic Studies Humans Medicine Seroprevalence Serologic Tests 030212 general & internal medicine education Aged Hepatitis B virus education.field_of_study Multidisciplinary Molecular medicine biology business.industry Malaysia Health care virus diseases Hepatitis C Middle Aged Hepatitis B medicine.disease Virology digestive system diseases Socioeconomic Factors Risk factors biology.protein Female 030211 gastroenterology & hepatology Antibody business |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-77813-5 |
| Popis: | Malaysia is a country with an intermediate endemicity for hepatitis B. As the country moves toward hepatitis B and C elimination, population-based estimates are necessary to understand the burden of hepatitis B and C for evidence-based policy-making. Hence, this study aims to estimate the prevalence of hepatitis B and C in Malaysia. A total of 1458 participants were randomly selected from The Malaysian Cohort (TMC) aged 35 to 70 years between 2006 and 2012. All blood samples were tested for hepatitis B and C markers including hepatitis B surface antigen (HBsAg), anti-hepatitis B core antibody (anti-HBc), antibodies against hepatitis C virus (anti-HCV). Those reactive for hepatitis C were further tested for HCV RNA genotyping. The sociodemographic characteristics and comorbidities were used to evaluate their associated risk factors. Descriptive analysis and multivariable analysis were done using Stata 14. From the samples tested, 4% were positive for HBsAg (95% CI 2.7–4.7), 20% were positive for anti-HBc (95% CI 17.6–21.9) and 0.3% were positive for anti-HCV (95% CI 0.1–0.7). Two of the five participants who were reactive for anti-HCV had the HCV genotype 1a and 3a. The seroprevalence of HBV and HCV infection in Malaysia is low and intermediate, respectively. This population-based study could facilitate the planning and evaluation of the hepatitis B and C control program in Malaysia. |
| Databáze: | OpenAIRE |
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