Comparison of cytogenetics, cytokine secretion, and oncogene expression in primary cultures of renal carcinoma cells
| Autor: | Albrecht Lindemann, I. Hentrich, Andreas Mackensen, Michael Lahn, Felicia Dr Rosenthal, Hendrik Veelken, Regina Kunzmann, Peter Kulmburg, David N. Iklé, Heike Jesuiter, Gabriele Köhler |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Biology medicine.disease_cause Proto-Oncogenes medicine Tumor Cells Cultured Humans Secretion HSP70 Heat-Shock Proteins Carcinoma Renal Cell Aged Chromosome 7 (human) Oncogene Epidermal Growth Factor Tumor Necrosis Factor-alpha Interleukins Cytogenetics Granulocyte-Macrophage Colony-Stimulating Factor General Medicine Middle Aged Transforming Growth Factor alpha medicine.disease Intercellular Adhesion Molecule-1 Primary tumor Drug Resistance Multiple Gene Expression Regulation Neoplastic Oncology Tumor progression Drug Resistance Neoplasm Cancer research Cytokines Cytokine secretion Female Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0030-2414 |
| Popis: | We compared the cytogenetic pattern of 20 different primary tumor cell cultures (PTCC) of renal cell carcinoma (RCC) to their cytokine secretion and oncogene expression. High secretion of IL-6 (gene locus on chromosome 7p21-p14) was correlated with the gain of an additional chromosome 7. Structural changes involving chromosome 5q22, the site of the GM-CSF gene, were matched with the high secretion of GM-CSF in PTCC. No such association was found for beta 2-microglobulin, TGF-beta 1, TNF-alpha, IL-8, and oncogenes, such as c-fos, c-myc, and pan-ras. Our approach may be useful in simultaneously analyzing several factors contributing to tumor progression and may contribute to understanding the multistep development of RCC. |
| Databáze: | OpenAIRE |
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