Human health risks related to the consumption of foodstuffs of animal origin contaminated by bisphenol A

Autor: Gorecki, Sébastien, Bemrah, Nawel, Roudot, Alain-Claude, Marchioni, Eric, Le Bizec, Bruno, Faivre, Franck, Kadawathagedara, Manik, Botton, Jérémie, Rivière, Gilles, EDEN mother-child cohort study group, .
Přispěvatelé: Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Université de Bretagne Occidentale, Université de Strasbourg (UNISTRA), Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), LUNAM Université [Nantes Angers Le Mans], Ministère de l'Agriculture et de l'Alimentation, Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) (SBIM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut national du cancer [Boulogne] (INCA)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Faculty of pharmacy, Université Paris-Sud - Paris 11 (UP11), Institut National de la Santé et de la Recherche Médicale (INSERM), Foundation for medical research (FRM), National Agency for Research (ANR) [ANR-06-BLAN-0359], National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), European Union FP7 programme (HELIX project), European Union FP7 programme (ESCAPE project), European Union FP7 programme (ENRIECO project), Diabetes National Research Program through a collaboration with the French Association of Diabetic Patients (AFD), French Agency for Environmental Health Safety, Mutuelle Générale de l'Education Nationale a complementary health insurance (MGEN), French national agency for food security, French speaking association for the study of diabetes and metabolism (ALFEDIAM), European Project: 261357,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,MEDALL(2010), Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut national du cancer [Boulogne] (INCA)-Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Rok vydání: 2017
Předmět:
Male
Animal food
Food contamination
010501 environmental sciences
Toxicology
01 natural sciences
Poultry
Non-canned food
Bisphenol A
Pregnancy
Food science
Child
Foodstuffs of animal origin
2. Zero hunger
education.field_of_study
Fishes
04 agricultural and veterinary sciences
General Medicine
Middle Aged
Contamination
040401 food science
Food Analysis
3. Good health
Conjugates
Child
Preschool
Female
France
Adult
Meat
Adolescent
Population
Biology
Young Adult
Health risk assessment
0404 agricultural biotechnology
Phenols
Environmental health
Animals
Humans
Benzhydryl Compounds
education
Aged
0105 earth and related environmental sciences
Exposure assessment
business.industry
Consumer Product Safety
Food processing
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Food Science
Food contaminant
Zdroj: Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2017, 110, pp.333-339. ⟨10.1016/j.fct.2017.10.045⟩
Food and Chemical Toxicology, 2017, 110, pp.333-339. ⟨10.1016/j.fct.2017.10.045⟩
ISSN: 0278-6915
DOI: 10.1016/j.fct.2017.10.045
Popis: International audience; Bisphenol A (BPA) is used in a wide variety of products and objects for consumers use (digital media such as CD's and DVD's, sport equipment, food and beverage containers, medical equipment). For humans, the main route of exposure to BPA is food. Based on previous estimates, almost 20% of the dietary exposure to BPA in the French population would be from food of animal origin. However, due to the use of composite samples, the source of the contamination had not been identified. Therefore, 322 individual samples of non-canned foods of animal origin were collected with the objectives of first updating the estimation of the exposure of the French population and second identifying the source of contamination of these foodstuffs using a specific analytical method. Compared to previous estimates in France, a decline in the contamination of the samples was observed, in particular with regard to meat. The estimated mean dietary exposures ranged from 0.048 to 0.050 μg (kg bw)(-1) d(-1) for 3-17 year children and adolescents, from 0.034 to 0.035 μg (kg bw)(-1) d(-1) for adults and from 0.047 to 0.049 μg (kg bw)(-1) d(-1) for pregnant women. The contribution of meat to total dietary exposure of pregnant women, adults and children was up to three times lower than the previous estimates. Despite this downward trend in contamination, the toxicological values were observed to have been exceeded for the population of pregnant women. With the aim of acquiring more knowledge about the origin the potential source(s) of contamination of non-canned foods of animal origin, a specific analytical method was developed to directly identify and quantify the presence of conjugated BPA (BPA-monoglucuronide, BPA-diglucuronide and sulphate forms) in 50 samples. No conjugated forms of BPAs were detected in the analysed samples, indicating clearly that BPA content in animal food was not due to metabolism but arise post mortem in food. This contamination may occur during food production. However, despite extensive sampling performed in several different shops (butcheries, supermarkets ....) and in different conditions (fresh, prepared, frozen ...), the source(s) of the contamination could not be specifically identified.
Databáze: OpenAIRE
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